造血干细胞移植治疗老年髓系肿瘤的临床分析  

Clinical analysis of hematopoietic stem cell transplantation for the treatment of elderly myeloid tumors

作　　者：郑雅龄 郑梓煜 吴明 杨楚婷 黄睿[1] 李玉华[1] Yaling Zheng;Ziyu Zheng;Ming Wu;Chuting Yang;Rui Huang;Yuhua Li(Department of Hematology,Zhujiang Hospital of Southern Medical University,Guangzhou 510282,China)

机构地区：[1]南方医科大学附属珠江医院血液内科,广州市510282

出　　处：《中国肿瘤临床》2024年第11期552-556,共5页Chinese Journal of Clinical Oncology

摘　　要：目的:探讨造血干细胞移植(hematopoietic stem cell transplantation,HSCT)对老年髓系肿瘤患者生存结局的影响。方法:回顾性分析2018年1月至2023年5月于南方医科大学附属珠江医院54例接受HSCT且年龄≥55岁髓系肿瘤患者的治疗结局。结果:54例患者中急性髓系白血病(acute myeloid leukemia,AML)患者45例,骨髓增生异常综合征患者9例,中位年龄57.5(55.0~68.0)岁。53例成功造血重建,中性粒细胞植入中位时间为13(8~24)天,血小板植入中位时间为15(9~75)天。急性移植物抗宿主病(graft-versus-host diseas,GVHD)累积发生率23.3%,3年慢性GVHD累积发生率24.6%。中位随访时间28.2个月,3年累积复发率(cumulative relapse rates,CIR)18.0%,3年非复发死亡率28.3%。3年无复发生存(relapse-free survival,RFS)率为58.2%,3年总生存(overall survival,OS)率为56.5%。结论:HSCT是老年髓系肿瘤患者获得长期生存的有效、安全的治疗手段。Objective To investigate the effect of hematopoietic stem cell transplantationon(HSCT)survival outcomes in older patients with myeloid neoplasms.Methods We retrospectively analyzed the treatment outcomes of 54 patients aged≥55 years with myeloid neoplasms who underwent HSCT between January 2018 and May 2023 at Zhujiang Hospital of Southern Medical University.Results Among the 54 patients,45 had acute myeloid leukemia(AML)and 9 had myelodysplastic syndrome.The median age of the patients was 57.5(55-68)years.Fifty-three patients underwent hematopoietic reconstitution,with a median time to neutrophil reconstitution of 13(8-24)days and median time to platelet reconstitution of 15(9-75)days.The cumulative incidence was 23.3%for acute graft-versus-host disease(GVHD)and 24.6%for 3-year chronic GVHD.With a median follow-up of 28.2 months,the 3-year cumulative relapse rate(CIR)was 18%and 3-year non-relapse mortality rate was 28.3%.The 3-year relapse-free survival(RFS)rate was 58.2%and 3-year overall survival(OS)rate was 56.5%.Conclusions HSCT is an effective and safe therapy for achieving long-term survival in older patients with myeloid tumors.

关 键 词：急性髓系白血病 骨髓增生异常综合征 老年 造血干细胞移植 

分 类 号：R733.71[医药卫生—肿瘤]