微波消融术联合全身化疗治疗结直肠癌根治术后肝转移的有效性及安全性分析  

Efficacy and safety analysis of microwave ablation combined with systemic chemotherapy for liver metastasis after radical resection of colorectal cancer

作　　者：谭永胜 石宝琪 张伟 王梁 TAN Yong-sheng;SHI Bao-qi;ZHANG Wei;WANG Liang(Interventional Diagnosis and Treatment Department,People's Hospital of Inner Mongolia Autonomous Region,Hohhot 010017,China)

机构地区：[1]内蒙古自治区人民医院介入诊疗科,呼和浩特010017

出　　处：《医药论坛杂志》2024年第13期1369-1371,1378,共4页Journal of Medical Forum

基　　金：内蒙古自治区卫生健康科技项目(202202036)。

摘　　要：目的回顾性分析微波消融术联合全身化疗治疗结直肠癌根治术后肝转移的效果及安全性。方法回顾性分析内蒙古自治区人民医院肿瘤内科和介入诊疗科在2020年1月至2022年12月时间段内的直肠癌根治术后异时性肝转移患者,依据患者相关检查符合微波消融及全身化疗条件者,随机分为参照组和联合组,每组随机抽样14例样本,共28例。参照组患者由肿瘤内科实施化疗手段治疗,联合组则由肿瘤内科全身静脉化疗2个周期后肿瘤无缩小或进展+微波消融术联合干预治疗,观察患者预后效果。结果在术后病情控制疗效方面,联合组与参照组几率为78.57%、50%,联合组病情控制更稳定,数据间差异性具有统计学意义(P<0.05)。术后不良反应联合组:白细胞减少2例,腹泻、恶心、呕吐1例总发生率14.29%(3/14);参照组:白细胞减少1例,腹泻、恶心、呕吐1例,总发生率21.43%(2/14),两组数据对比,差异无统计学意义(P>0.05)。结论结直肠癌根治术后肝转移患者,全身化疗后进展采取联合微波消融术治疗方案,有效缓解临床体征,具有较高的有效性和安全性,推荐价值极高。Objective To retrospectively analyze the effect and safety of microwave ablation combined with systemic chemotherapy in treating liver metastasis after radical resection of colorectal cancer.Methods Retrospective analysis of the oncology and interventional clinic of Inner Mongolia autonomous region people's hospital from Jan.2020 to Dec.2022 rectal cancer radical postoperative patients with abnormal liver metastasis,according to the conditions of microwave ablation and systemic chemotherapy,they were randomly divided into reference group and combined group,each group random cases 14,a total of 28 cases.In the reference group,the patients were treated by chemotherapy from the department of oncology,while in the combined group,the tumor intervention after two cycles of systemic intravenous chemotherapy,was used to observe the prognosis effect of the patients.Results In terms of the efficacy of postoperative disease control,the combination and reference groups were 78.57%and 50%,and the condition control was more stable,and the data difference was statistically significant(P<0.05).Combination group of postoperative adverse reactions:2 cases of leukopenia,the total incidence of diarrhea,nausea,and vomiting was 14.29%(3/14);reference group:1 case of leukopenia,1 case of diarrhea,nausea,and vomiting,the total incidence was 21.43%(2/14),the two groups(P>0.05).Conclusion Patients with liver metastasis after radical resection of colorectal cancer are combined with microwave ablation,effectively alleviating clinical signs,with high effectiveness and safety,and high recommended value.

关 键 词：微波消融术 全身化疗 结直肠癌根治 肝转移 安全性 有效性 

分 类 号：R735.34[医药卫生—肿瘤]