骨肉瘤组织中CD44、CD34及Livin的表达水平及临床意义  

Expression levels of CD44,CD34 and Livin in osteosarcoma tissues and their clinical significance

作　　者：张鑫[1] 苗巍[1] 张之智[1] 卢伟[1] ZHANG Xin;MIAO Wei;ZHANG Zhi-Zhi;LU Wei(Central Hospital of Jiaozuo Coal Industry Group Co.LTD.,Jiaozuo,Henan 454000,China)

机构地区：[1]焦作煤业集团有限公司中央医院骨科,河南焦作454000

出　　处：《医药论坛杂志》2024年第13期1403-1408,共6页Journal of Medical Forum

摘　　要：目的探讨骨肉瘤组织中白细胞分化抗原44(CD44)、白细胞分化抗原34(CD34)及Livin的表达水平及临床意义。方法收集2014年2月至2015年7月焦作煤业集团有限公司中央医院诊治的90例骨肉瘤患者的临床资料和随访资料进行回顾性分析。检测骨肉瘤组织和非瘤性骨组织中CD44、CD34及Livin的表达。采用Kaplan-Meier法分析患者生存状况,多因素Cox回归分析预后不良影响因素。结果与非瘤性骨组织相比,骨肉瘤组织中CD44、CD34及Livin的表达阳性率明显上调(P<0.05)。骨肉瘤组织中CD44、CD34及Livin的表达与骨肉瘤Ennecking分期和远处转移相关(P<0.05)。CD44、CD34及Livin阴性患者的5年总生存率明显高于阳性患者(P<0.05)。Ennecking分期Ⅲ期、远处转移、CD44阳性、CD34阳性、Livin阳性为骨肉瘤患者预后不良的独立风险因素(P<0.05)。结论骨肉瘤组织中CD44、CD34及Livin的表达阳性率明显高于非瘤性骨组织,并且与骨肉瘤Ennecking分期、远处转移和预后相关。Objective To investigate the expression levels of CD44,CD34 and Livin in osteosarcoma tissues and their clinical significance.Methods Clinical data and follow-up data of 90 patients with osteosarcoma treated in Central Hospital of Jiaozuo Coal Industry Group Co.LTD from February 2014 to July 2015 were collected for retrospective analysis.Expression of CD44,CD34 and Livin in osteosarcoma and non-neoplastic bone tissue were detected.The Kaplan-Meier method was used to analyze patient survival and multi-factor Cox regression to analyze factors influencing poor prognosis.Results Compared with non-neoplastic bone tissue,the positive rates of CD44,CD34 and Livin in osteosarcoma tissues were significantly up-regulated(P<0.05).Expression of CD44,CD34 and Livin in osteosarcoma was correlated with Ennecking stage and distant metastasis(P<0.05).The 5-year overall survival rate of CD44,CD34 and Livin negative patients was significantly higher than that of positive patients(P<0.05).Ennecking stage III,distant metastasis,CD44 positivity,CD34 positivity and Livin positivity were independent risk factors for poor prognosis in patients with osteosarcoma(P<0.05).Conclusion The positive rates of CD44,CD34 and Livin expression in osteosarcoma tissues were significantly higher than that in non-neoplastic bone tissues,and were associated with Ennecking stage,distant metastasis and prognosis of osteosarcoma.

关 键 词：骨肉瘤 白细胞分化抗原44 白细胞分化抗原34 LIVIN 预后 病理特征 

分 类 号：R738.1[医药卫生—肿瘤]