天然多酚纳米微粒材料研究进展及在癌症治疗中的应用  

Research progress on natural polyphenol nanoparticles and their applications in cancer therapy

作　　者：范广宇 黎迎[2] 张倩倩 陈星历 董政起[2] 李鑫[1] 陆洋 FAN Guangyu;LI Ying;ZHANG Qianqian;CHEN Xingli;DONG Zhengqi;LI Xin;LU Yang(School of Pharmacy,Harbin University of Commerce,Harbin 150076,China;Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100193,China;Guangling College of Yangzhou University,Yangzhou 225000,China;School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]哈尔滨商业大学药学院,黑龙江哈尔滨150076 [2]中国医学科学院北京协和医学院药用植物研究所,北京100193 [3]扬州大学广陵学院,江苏扬州225000 [4]北京中医药大学中药学院,北京100029

出　　处：《中草药》2024年第14期4953-4961,共9页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82304733);中国医学科学院医学与健康科技创新工程(2021-I2M-1-022)。

摘　　要：多酚纳米微粒以其独特的特性,为癌症治疗提供了崭新的前景,在医药、食品和化妆品等领域受到广泛关注。天然多酚中的多酚结构通过多种氢键和疏水相互作用,及与硼酸基团和多种金属离子的动态共价络合,形成了很强的非共价作用进一步合成了各类多酚纳米微粒。多酚纳米微粒具有出色的癌细胞靶向性能,也是优秀的药物递送平台,在癌症治疗中展现出潜在的治疗能力。通过概述多酚纳米微粒在癌症治疗中的应用,并对天然多酚基水凝胶、纳米微粒和聚合物的功能特性进行综述。强调了多酚纳米微粒在癌细胞靶向、药物递送、光响应、磁响应和治疗中的多重作用,为天然多酚纳米微粒材料的研发及癌症领域治疗提供新思路。Polyphenol nanoparticles with their unique properties provide a new prospect for cancer treatment,and have been widely concerned in the fields of medicine,food and cosmetics.The polyphenol structure in natural polyphenols forms a stron g non-covalent interaction through a variety of hydrogen bonds and hydrophobic interactions,as well as dynamic covalent complexation with boric acid groups and various metal ions,and further synthesizes various polyphenol nanoparticles.Polyphenol nanoparticles have excellent cancer cell targeting properties and are also excellent drug delivery platforms.Most importantly,polyphenol nanoparticles have shown potential therapeutic power in cancer treatment.In this paper,the applicat ion of polyphenol nanoparticles in cancer therapy and the functional properties of natural polyphenol-based hydrogels,nanoparticles and polymers were reviewed.The multiple roles of polyphenol nanoparticles in cancer cell targeting,drug delivery,photoresponse,magnetic response and therapy were emphasized,providing new ideas for the research and development of natural polyphenol nanoparticles and cancer treatment.

关 键 词：多酚 纳米微粒 癌症治疗 水凝胶 药物递送 光响应智能释药系统 磁响应智能释药系统 

分 类 号：R283[医药卫生—中药学]