人工智能技术评估脊髓小脑共济失调3型患者脑萎缩的应用价值  

The application value of artificial intelligence in evaluating brain atrophy in patients with spinocerebellar ataxia type 3

作　　者：陈思丹 吴交交 曹伯裕 许框慧 李雨钢 胡宙瑶 花蕊 石峰 王小川[3] 戚乐[1] CHEN Sidan;WU Jiaojiao;CAO Boyu;XU Kuanghui;LI Yugang;HU Zhouyao;HUA Rui;SHI Feng;WANG Xiaochuan;QI Le(Department of Radiology,the Affiliated Hospital of Hangzhou Normal University,Hangzhou 310015,China;Shanghai United Imaging Intelligence Co.,Ltd.,Shanghai 200232,China;Department of Neurology,the Affiliated Hospital of Hangzhou Normal University,Hangzhou 310015,China)

机构地区：[1]杭州师范大学附属医院放射科,浙江杭州310015 [2]上海联影智能医疗科技有限公司,上海200232 [3]杭州师范大学附属医院神经内科,浙江杭州310015

出　　处：《实用放射学杂志》2024年第7期1037-1042,共6页Journal of Practical Radiology

基　　金：杭州师范大学附属医院研究生科技研究项目(2021YN174);杭州市生物医药和健康产业发展扶持专项项目(2023WJC067)。

摘　　要：目的基于人工智能(AI)技术评价脊髓小脑共济失调3型(SCA3)患者脑萎缩程度,探讨其与疾病严重程度的相关性。方法收集SCA3患者(SCA3组)23例和健康对照(HC)(HC组)24例的临床资料和影像数据。使用国际合作共济失调评分量表(ICARS)评估SCA3患者共济失调严重程度。采用AI技术处理SCA3组和HC组的3D-T1WI MR影像数据,分割及测量脑组织的体积及其体积百分比。统计分析SCA3患者脑组织结构改变与共济失调严重程度的相关性。结果2组间性别、年龄比较无统计学差异(P>0.05)。与HC组比较,SCA3组额叶、颞叶、顶叶、枕叶、边缘叶、右侧大脑白质、皮层下灰质、小脑及脑干体积及体积百分比显著下降(多重假设检验校正后P<0.01)。SCA3组的ICARS与患者的年龄呈正相关(r=0.571,P=0.004),与左侧小脑白质、小脑蚓部、延髓的体积及双侧小脑白质、小脑蚓部、脑桥、延髓的体积百分比均呈负相关(P<0.05)。结论SCA3患者幕上以及幕下脑组织均存在萎缩,其中苍白球萎缩最为显著,提示其可以作为SCA3的影像标志物之一。Objective To evaluate the degree of brain atrophy in spinocerebellar ataxia type 3(SCA3)patients based on artificial intelligence(AI)technology,and to explore the correlation between the degree of brain atrophy and the severity of the disease.Methods The clinical and imaging data of 23 SCA3 patients(SCA3 group)and 24 healthy controls(HC)(HC group)were collected.The International Cooperative Ataxia Rating Scale(ICARS)was used to evaluate the severity of ataxia in patients with SCA3.AI technology was used to process the 3D-T1WI MR image data of the SCA3 and HC groups to segment and measure the volume and volume percentage of brain,followed by correlation analyses between brain structural alterations and the severity of ataxia in SCA3 patients.Results There were no significant differences in gender and age between the two groups(P>0.05).The SCA3 group had a significant reduction in the volume and volume percentage of various brain regions,such as the frontal,temporal,parietal,occipital,limbic,right cerebral white matter,subcortical gray matter,cerebellum and brainstem,compared to the HC group(multiple hypothesis testing adjusted P<0.01).In the SCA3 group,the ICARS showed positive correlation with patient age(r=0.571,P=0.004)and negative correlation with the volume of the left cerebellar white matter,vermis,medulla oblongata,and the volume percentages of bilateral cerebellar white matter,vermis,pons,medulla oblongata(P<0.05).Conclusion The significant atrophy of the supratentorial and subtentorial regions of the brain in SCA3 patients.The globus pallidus exhibits the most substantial atrophy,suggesting its potential as an imaging diagnostic marker of SCA3.

关 键 词：人工智能 脊髓小脑共济失调3型 脑萎缩 磁共振成像 

分 类 号：TP181[自动化与计算机技术—控制理论与控制工程] R744[自动化与计算机技术—控制科学与工程] R742[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]