肠道菌群在功能性便秘发病机制中的研究进展  

Research progress of intestinal flora in pathogenesis of functional constipation

作　　者：张晓梅 蒋捷[3] 陈昊 孙建华 宋亚芳 盛钰翔 Zhang Xiaomei;Jiang Jie;Chen Hao;Sun Jianhua;Song Yafang;Sheng Yuxiang(The First Clinical Medical School,Nanjing University of Traditional Chinese Medicine,Nanjing,Jiangsu 210029,China;Community Health Service Center of Yushan Subdistrict,Changshu,Jiangsu 215500,China;Changshu Hospital of TCM Affiliated to Nanjing University of Traditional Chinese Medicine,Changshu,Jiangsu 215500,China;School of Acupuncture and Manipulation,Nanjing University of Traditional Chinese Medicine,Nanjing,Jiangsu 210023,China;School of Acupuncture and Manipulation&School of Health and Rehabilitation,Nanjing University of Traditional Chinese Medicine,Nanjing,Jiangsu 210023,China;Nanjing TCM Hospital Affiliated to Nanjing University of Traditional Chinese Medicine,Nanjing,Jiangsu 210002,China)

机构地区：[1]南京中医药大学第一临床医学院,江苏南京210029 [2]虞山街道社区卫生服务中心,江苏常熟215500 [3]南京中医药大学附属常熟市中医院,江苏常熟215500 [4]南京中医药大学针灸推拿学院,江苏南京210023 [5]南京中医药大学针灸推拿学院·养生康复学院,210023 [6]南京中医药大学附属南京中医院,江苏南京210022

出　　处：《齐齐哈尔医学院学报》2024年第15期1445-1449,共5页Journal of Qiqihar Medical University

基　　金：国家自然科学基金(82274630);横向课题(HYCMP-2021005);江苏省中医药管理局(QN202101);常熟市科学技术局(CS202244、CS202227)。

摘　　要：功能性便秘(functional constipation,FC)是常见的胃肠道疾病,近年来,生活方式改变伴随着功能便秘全球发病率逐年递增,不仅通过降低患者食欲、生活质量从而影响工作效率及心理健康,还严重增加了心血管、内分泌及肛肠精神疾病患病的风险,其发病机制尚不完全清楚。近年来,越来越多证据表明,肠道微生态失衡在FC的发展中发挥着非常重要的作用,在治疗FC时恢复肠道菌群平衡对于改善便秘相关症状有着非常重要的意义。应用微生态制剂、粪菌移植及中医药调节肠道微生态是治疗FC的研究热点。本文旨在从肠道菌群角度探讨FC的发病机制及微生态因子、中医疗法的治疗机制,为FC的治疗提供新的管理策略。Functional constipation(FC)is a common gastrointestinal disease.The global incidence of FC has been rising annually in recent years,a trend correlated with changes in lifestyle.It affects work efficiency and mental health by reducing appetite and quality of life of patients.It also significantly elevates the risk of cardiovascular,endocrine and anorectal psychiatric diseases,the pathogenesis of which is not fully understood.In recent years,more and more evidence has shown that intestinal microecological imbalance plays a very important role in the development of FC,and restoring the balance of intestinal flora in the treatment of FC has a very important significance in improving constipation related symptoms.The application of microecological preparations,fecal bacteria transplantation and traditional Chinese medicine to regulate intestinal microecology is a hot topic in the treatment of FC.This paper aims to explore the pathogenesis and microecological factors of FC and the therapeutic mechanism of traditional Chinese medicine from the perspective of intestinal flora,and provide a new management strategy for the treatment of FC.

关 键 词：功能性便秘 肠道菌群 微生态治疗 中医药治疗 针灸 

分 类 号：R574.62[医药卫生—消化系统]