MutL蛋白同系物1/MutS蛋白同系物2表达缺失与弥漫浸润型胃癌临床病理特征及预后关系  

Relationship between MutL protein homologue 1/MutS protein homologue 2 expression loss and clinicopathological features and prognosis of diffuse gastric cancer

作　　者：朱炎焱 古骏 邹俊伟 吴兆映 韩艳丽 ZHU Yanyan;GU Jun;ZOU Junwei;WU Zhaoying;HAN Yanli(Department of Oncology,the Second Affiliated Hospital of Wannan Medical College,Anhui Province,Wuhu241000,China;Department of Gastroenterology,the Second Affiliated Hospital of Wannan Medical College,Anhui Province,Wuhu241000,China;Department of Gastrointestinal Surgery,the Second Affiliated Hospital of Wannan Medical College,Anhui Province,Wuhu241000,China;Department of Pathology,the Second Affiliated Hospital of Wannan Medical College,Anhui Province,Wuhu241000,China)

机构地区：[1]皖南医学院第二附属医院肿瘤科,安徽芜湖241000 [2]皖南医学院第二附属医院消化科,安徽芜湖241000 [3]皖南医学院第二附属医院胃肠外科,安徽芜湖241000 [4]皖南医学院第二附属医院病理科,安徽芜湖241000

出　　处：《中国医药导报》2024年第16期97-99,106,共4页China Medical Herald

基　　金：安徽省高等学校自然科学研究重点项目(2023AH051777)。

摘　　要：目的探讨MutL蛋白同系物1(MLH1)/MutS蛋白同系物2(MSH2)表达缺失与弥漫浸润型胃癌临床病理特征及预后关系。方法回顾性分析2020年3月至2022年7月皖南医学院第二附属医院收治的157例弥漫浸润型胃癌患者的临床资料,分析MLH1/MSH2表达缺失与弥漫浸润型胃癌临床病理特征的关系,随访1年,记录患者生存情况,分析弥漫浸润型胃癌患者预后的影响因素。结果157例患者中,MLH1/MSH2表达缺失16例,缺失率为10.19%。低分化、Ⅲ期、淋巴结转移的患者MLH1/MSH2表达缺失率高于中高分化、Ⅰ~Ⅱ期、淋巴结未转移患者,差异有统计学意义(P<0.05)。随访1年,MLH1/MSH2表达未缺失患者生存曲线优于MLH1/MSH2表达缺失患者,差异有统计学意义(P<0.05)。TNM分期、术后并发症、MLH1/MSH2表达缺失为弥漫浸润型胃癌患者预后的危险因素(P<0.05)。结论MLH1/MSH2表达缺失与弥漫浸润型胃癌患者肿瘤分化程度、TNM分期、淋巴结转移及预后密切相关,且MLH1/MSH2表达缺失者预后更差。Objective To investigate the relationship between the MutL protein homologue 1(MLH1)/MutS protein homologue 2(MSH2)expression loss and the clinicopathological features and prognosis of diffuse invasive gastric cancer.Methods Clinical data of 157 patients with diffuse invasive gastric cancer admitted to the Second Affiliated Hospital of Wannan Medical College from March 2020 to July 2022 were retrospectively analyzed,and the relationship between MLH1/MSH2 expression loss and clinicopathological features of diffuse invasive gastric cancer was analyzed.The survival of patients was recorded during 1-year follow-up,and the factors influencing prognosis of patients with diffuse invasive gastric cancer were analyzed.Results Among 157 patients,MLH1/MSH2 expression loss was 16 cases(10.19%).The loss rate of MLH1/MSH2 expression in patients with low differentiation,stageⅢ,and lymph node metastasis was higher than patients with medium and high differentiation,stageⅠtoⅡ,and no lymph node metastasis and the difference was statistically significant(P<0.05).After one-year follow-up,the survival curve of patients without MLH1/MSH2 expression loss was better than patients with MLH1/MSH2 expression loss and the difference was statistically significant(P<0.05).TNM stage,postoperative complications,and MLH1/MSH2 expression loss were risk factors for prognosis in patients with diffuse invasive gastric cancer(P<0.05).Conclusion The MLH1/MSH2 expression loss is closely related to tumor differentiation,TNM stage,lymph node metastasis and prognosis of patients with diffuse invasive gastric cancer,and the prognosis of patients with MLH1/MSH2 expression loss is worse.

关 键 词：MutL蛋白同系物1/MutS蛋白同系物2 弥漫浸润型胃癌 临床病理特征 预后 

分 类 号：R730[医药卫生—肿瘤]