LncRNA TP73-AS1调控消化系统恶性肿瘤的作用机制及其研究进展  

Mechanism and research progress of lncRNA TP73-AS1 regulating digestive system malignant tumors

作　　者：石敏 杨刚 郝彦琴[1] SHI Min;YANG Gang;HAO Yanqin(Department of Infectious Diseases,the First Hospital of Shanxi Medical University,Shanxi Province,Taiyuan030001,China;Department of General Surgery,the Second Hospital of Shanxi Medical University,Shanxi Province,Taiyuan030001,China)

机构地区：[1]山西医科大学第一医院感染病科,山西太原030001 [2]山西医科大学第二医院普通外科,山西太原030001

出　　处：《中国医药导报》2024年第16期191-193,共3页China Medical Herald

基　　金：山西省基础研究计划项目(20210302123436)。

摘　　要：长链非编码RNAs(lncRNA)是一类长度超过200个核苷酸的非编码转录本。LncRNA在癌症的发生和发展中起着重要的调控作用。肿瘤蛋白P73反义RNA1(TP73-AS1)是一种新型lncRNA,在食管癌、肝癌、胃癌及结直肠癌等消化系统恶性肿瘤中异常表达,并与肿瘤的发生、发展关系密切,影响患者的生存和预后。本文通过阐述TP73-AS1在消化道恶性肿瘤中的作用机制及临床意义,为今后的基础和临床研究提供参考。Long non-coding RNA(lncRNA)are a class of non-coding transcripts that are more than 200 nucleotides long.lncRNA play an important regulatory role in the occurrence and development of cancer.Tumor protein P73 antisense RNA1(TP73-AS1)is a novel lncRNA,which is abnormally expressed in digestive system malignant tumors such as esophageal cancer,liver cancer,stomach cancer,and colorectal cancer,and is closely related to the occurrence and development of tumors,affecting the survival and prognosis of patients.This paper elucidates the mechanism and clinical significance of TP73-AS1 in gastrointestinal malignant tumors,and provides reference for future basic and clinical research.

关 键 词：长链非编码RNA 肿瘤蛋白P73反义RNA1 消化系统恶性肿瘤 机制 

分 类 号：R735[医药卫生—肿瘤]