中药放射增敏机制的研究进展  

Research Progress on Radiosensitization Mechanism of Traditional Chinese Medicine

作　　者：蒋磊 胡莉钧 潘玉艳 周海俊 郝卫强 高潮[1] 岩桥均 高桥淳子 JIANG Lei;HU Li-jun;PAN Yu-yan;ZHOU Hai-jun;HAO Wei-qiang;GAO Chao;IWAHASHI Hitoshi;TAKAHASHI Junko(School of Inspection and Testing Certification,Changzhou Vocational Institute of Engineering,Changzhou 213164 Jiangsu,China;Department of Radiation Oncology,the Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University,Changzhou 213000 Jiangsu,China;Department of Pharmacy,the Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University,Changzhou 213003 Jiangsu,China;Faculty of Applied Biological Sciences,Gifu University,Gifu Shi 501-1193 Gifu Ken,Japan;Graduate School of Information,Production and Systems,Waseda University,Kitakyushu Shi 808-0135 Fukuoka Ken,Japan)

机构地区：[1]常州工程职业技术学院检验检测认证学院,江苏常州213164 [2]南京医科大学附属常州第二人民医院放疗科,江苏常州213000 [3]南京医科大学附属常州第二人民医院药学部,江苏常州213003 [4]岐阜大学应用生物科学部,日本岐阜县岐阜市501-1193 [5]早稻田大学信息、生产和系统研究科(IPS),日本福冈县北九州市808-0135

出　　处：《中医肿瘤学杂志》2024年第4期73-77,94,共6页Journal of Oncology in Chinese Medicine

基　　金：江苏省高等学校基础科学(自然科学)研究项目资助(编号:22KJD350001);江苏省高校优秀科技创新团队项目;江苏高校“青蓝工程”项目。

摘　　要：放疗是癌症治疗重要的手段之一,然而高剂量放疗引起的放射性炎症和肿瘤放射抵抗严重影响了患者治疗的依从性和成功率。放射增敏剂可有效提高肿瘤细胞放射敏感性,促进射线对肿瘤细胞的杀伤作用,对临床至关重要。本文回顾近五年全球中药作为放射增敏剂的增敏机制及在癌症放疗中的潜在应用价值,筛选可作为新型放射增敏剂的候选中药。本文使用关键词对PubMed、Scopus、Google Scholar和中国知网等科学数据库进行检索,对相关基础和临床研究的数据和结果进行综述。研究发现国内外中药作为放射增敏剂的研究具有一定基础。单体、复方、草本提取物和新型纳米中药均展现了潜在的应用价值,放射增敏机制主要为调节癌症细胞凋亡途径或细胞周期阻滞相关的基因。Radiotherapy is one of the important means of cancer treatment.However,radiation inflammation and tumor radioresistance caused by high-dose radiotherapy seriously affect the patients’treatment compliance and success rate.Radiosensitizer can effectively increase the radiosensitivity of tumor cells and promote the killing effect of radiation on tumor cells,which is of great importance in clinical practice.This paper reviewed the sensitization mechanisms of traditional Chinese medicines(TCMs)as radiosensitizers and their potential application value in cancer radiotherapy in the past five years,and screened candidate TCMs that could be used as new radiosensitizers.Scientific databases such as PubMed,Scopus,Google Scholar,and China National Knowledge Infrastructure(CNKI)were searched by using keywords,and the data and results of relevant basic and clinical research were reviewed.It was found that there was a certain foundation for the research of TCMs as radiosensitizers at domestic and abroad.Monomers,prescriptions,herbal extracts,and novel nanomedicines showed potential application value.The radiosensitization mechanisms were mainly related to regulate cancer cell apoptosis pathways or genes of cell cycle arrest.

关 键 词：放疗 放射增敏剂 中草药 

分 类 号：R932[医药卫生—生药学] R979.1[医药卫生—药学]