基于脑肠轴探讨健脾化痰法治疗脑瘤的研究进展  

Research Progress of Invigorating Spleen and Eliminating Phlegm in the Treatment of Brain Tumor Based on Brain-Gut Axis

作　　者：李宝英 张军 刘欣 赵翘楚 曹芳[3] LI Bao-ying;ZHANG Jun;LIU Xin;ZHAO Qiao-chu;CAO Fang(The First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Jinan 250013 Shandong,China;Traditional Chinese Medicine Innovation Research Institute,Shandong University of Traditional Chinese Medicine,Jinan 250355 Shandong,China;Department of Oncology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014 Shandong,China)

机构地区：[1]山东中医药大学第一临床医学院,山东济南250013 [2]山东中医药大学中医药创新研究院,山东济南250355 [3]山东中医药大学附属医院肿瘤科,山东济南250014

出　　处：《中医肿瘤学杂志》2024年第4期78-84,共7页Journal of Oncology in Chinese Medicine

摘　　要：脑瘤是一类发生于颅脑腔内的良性或恶性肿瘤,本病发病机制复杂,危及患者的生命健康。目前现代医学与中医学对脑瘤的治疗虽取得一定成果,但仍没有普遍有效的疗法,需进一步研究脑瘤治疗的新方法。近年来,现代医学认识到脑肠轴、肠道菌群与脑瘤三者之间密切相关。中医认为,脑肠轴是整体观念的体现,肠道菌群与脾胃的概念相似,脑、肠与脾胃之间存在深刻的联系,脾虚无力运行水液,而生痰湿,痰湿上达脑窍,发为脑瘤,脾虚痰湿为脑瘤的主要病机。因此,基于脑肠轴理论以健脾化痰法治疗脑瘤具有临床指导意义。笔者总结了健脾化痰法对肠道菌群及脑瘤的具体作用,进一步为健脾化痰法治疗脑瘤的可行性和有效性提供了理论依据。通过从中西医角度论述脑肠轴、肠道菌群、脾胃和脑瘤的关系,就健脾化痰法在脑瘤治疗中的作用进行综述探讨,以期为临床治疗脑瘤提供新思路。Brain tumors are a type of benign or malignant tumors that occur within the cranial cavity.The disease mechanism is complex,posing a threat to the patient’s life and health.At present,although modern medicine and traditional Chinese medicine(TCM)have made some achievements in the treatment of brain tumor,an universally effective treatment remains elusive,necessitating further exploration of novel therapeutic approaches.In recent years,modern medicine has acknowledged the intimate relationship among the brain-gut axis,intestinal microbiota,and brain tumor.According to TCM,the brain-gut axis embodies holistic concept,with intestinal microbiota conceptually akin to spleen and stomach,establishing profound connections among brain,intestine,and spleen and stomach.Spleen deficiency hampers fluid regulation,leading to the production of phlegmdampness,which can ascend to brain and manifest as brain tumor,constituting the primary pathogenesis.Thus,based on the theory of the brain-gut axis,spleen invigoration and phlegm elimination in the treatment of brain tumor holds significant clinical guidance.This paper delineated the specific impacts of spleen invigoration and phlegm elimination on intestinal microbiota and brain tumor,offering a theoretical foundation for the feasibility and efficacy of this therapeutic approach.Furthermore,it analyzed the interplay among the brain-gut axis,intestinal microbiota,spleen and stomach,and brain tumor from both TCM and western medicine perspectives,exploring the role of spleen invigoration and phlegm elimination in brain tumor treatment to provide innovative clinical strategies.

关 键 词：脑瘤 脑肠轴 肠道菌群 脾胃 健脾化痰法 

分 类 号：R739.41[医药卫生—肿瘤] R273[医药卫生—临床医学]