通天口服液联合丁苯酞治疗急性后循环脑梗死的临床研究  

Clinical Study on the Treatment of Acute Posterior Circulation Cerebral Infarction with Tongtian Oral Liquid Combined with butylphthalide

作　　者：王理[1] 禹小杜[1] 黄玉涓 李枝 郭发辉 游道锋[2] WANG Li;YU Xiaodu;HUANG Yujuan;LI Zhi;GUO Fahui;YOU Daofeng(Department of Neurology,the Fourth Hospital of Changsha City,Changsha,Hunan 410006,China;The First Hospital of Hebei Medical University,Shijiazhuang,Hebei 050031,China)

机构地区：[1]湖南省长沙市第四医院神经内科,长沙410006 [2]河北医科大学第一医院,石家庄050031

出　　处：《重庆医学》2024年第S01期5-8,共4页Chongqing Medical Journal

基　　金：湖南省卫生健康委员会科研项目(202203073343)。

摘　　要：目的探讨通天口服液联合丁苯酞治疗急性后循环脑梗死的疗效。方法选取2022年1月至2023年7月该院神经内科收治的80例急性后循环梗死患者为研究对象,分为观察组和对照组,每组40例。两组均予以常规治疗,对照组静脉滴注丁苯酞注射液,观察组在对照组基础上加用通天口服液。比较两组临床疗效、NIHSS评分、高敏-C-反应蛋白(hs-CRP)、纤维蛋白原(FIB)、白细胞介素-6(IL-6)水平和不良发生情况(治疗后ALT异常、血肌酐异常)。结果观察组总有效率高于对照组(92.5%vs.75.0%),差异有统计学意义(P<0.05),治疗后两组NIHSS评分较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后两组hs-CRP、FIB、IL-6水平较治疗前降低,差异有统计学意义(P<0.05)。观察组NIHSS评分和FIB水平下降幅度明显高于对照组,差异有统计学意义(P<0.05)。两组hs-CRP和IL-6下降幅度比较,差异无统计学意义(P>0.05)。两组均无ALT异常和/或血肌酐异常发生。结论通天口服液联合丁苯酞注射液用于治疗急性后循环脑梗死,较单用丁苯酞注射液具有更好的临床疗效。Objective To investigate the curative effect of Tongtian oral liquid combined with butylphthalide in the treatment of acute posterior circulating cerebral infarction.Methods A total of 80 patients with acute post-circulation infarction admitted to the Department of Neurology of this hospital from January 2022 to July 2023 were selected as the study objects and divided into observation group and control group,with 40 cases in each group.Both groups were given routine treatment,the control group was given butylphthalide injection,and the observation group was given Tongtian oral liquid on the basis of the control group.The clinical efficacy,NIHSS score,levels of hypersensitive C-reactive protein(hs-CRP),fibrinogen(FIB),interleukin-6(IL-6)and adverse events(abnormal ALT and abnormal serum creatinine after treatment)were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(92.5%vs.75.0%),the difference was statistically significant(P<0.05).The NIHSS score of the two groups after treatment was lower than that before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).After treatment,the levels of hs-CRP,FIB and IL-6 in the two groups were lower than those before treatment,and the difference was statistically significant(P<0.05).The decrease of NIHSS score and FIB level in observation group was significantly higher than that in control group,and the difference was statistically significant(P<0.05).There was no significant difference in the decrease of hs-CRP and IL-6 between the two groups(P>0.05).There was no abnormal ALT and/or abnormal creatinine in either group.Conclusion Tongtian oral liquid combined with butylphthalide injection has better clinical efficacy than butylphthalide injection alone in the treatment of acute post-circulation cerebral infarction.

关 键 词：脑梗死 后循环 通天口服液 丁苯酞 

分 类 号：R743.33[医药卫生—神经病学与精神病学]