不同化疗方案对肺癌合并恶性胸腔积液的疗效研究  

Study on the Therapeutic Effect of Different Chemotherapy Regimens on Lung Cancer Combined with Malignant Pleural Effusion

作　　者：杨金国 国庆强 王菲菲 YANG Jinguo;GUO Qingqiang;WANG Feifei(Jiyang District People's Hospital Emergency department,Ji'nan 250000,China)

机构地区：[1]济阳区人民医院急诊科,山东济南250000

出　　处：《中华灾害救援医学》2024年第5期524-526,共3页Chinese Journal of Disaster Medicine

基　　金：2023年济南市卫生健康委员会科技计划项目(2023-1-66)。

摘　　要：目的探索不同化疗方案对肺癌伴胸腔积液患者的疗效。方法选取2020年1月至2023年12月济阳区人民医院收治的110例肺癌伴胸腔积液患者为研究对象,根据化疗方案的不同,分为观察组和对照组,每组55例。观察组采取卡铂、博来霉素、干扰素、白介素联合胸腔灌注的化疗方案,对照组采取单独卡铂灌注化疗方案。对比两组患者疗效、生活质量和不良反应。结果观察组患者胸腔积液治疗有效率为83.64%,显著高于对照组的43.64%(P<0.001)。化疗前,两组患者生活质量4个维度评分均无显著差异(P>0.05);化疗后,两组患者生活质量4个维度评分均明显升高,观察组患者心理功能、情绪功能、生理功能、社会功能评分均显著高于对照组(P<0.001)。观察组不良反应发生率为34.55%,与对照组的41.82%相比无显著差异(P=0.432)。结论卡铂、博来霉素、干扰素、白介素联合胸腔灌注化疗方案,能有效减少肺癌伴胸腔积液患者的胸腔积液量,改善生活质量,且安全性高。Objective To explore the efficacy of different chemotherapy regimens in patients with lung cancer and pleural effusion.Methods 110 patients with lung cancer and pleural effusion admitted to Jiyang District People’s Hospital from January 2020 to December 2023 were selected as study subjects and were divided into the observation group and the control group,with 55 cases in each group,according to different chemotherapy regimens.The observation group was treated with carboplatin,bleomycin,interferon,interleukin combined with pleural perfusion chemotherapy,and the control group was treated with a single carboplatin perfusion chemotherapy regimen.The efficacy,quality of life and adverse reactions of the two groups were compared.Results The effective rate of pleural effusion in the observation group was 83.64%,which was significantly higher than that in the control group(43.64%)(P<0.001).There was no significant difference in the scores of the four dimensions of quality of life between the two groups before chemotherapy(P>0.05),and after chemotherapy,the scores of the four dimensions of quality of life were significantly higher than those before chemotherapy,and the scores of psychological function,emotional function,physiological function and social function in the observation group were significantly higher than those in the control group(P<0.001).The incidence of adverse reactions in the observation group was 34.55%,which was not significantly different from that in the control group(41.82%)(P=0.432).Conclusion Carboplatin,bleomycin,interferon and interleukin combined with pleural perfusion chemotherapy can effectively reduce the amount of pleural effusion in patients with lung cancer and pleural effusion,improve the quality of life,and have high safety.

关 键 词：胸腔积液 恶性 肺肿瘤 抗肿瘤联合化疗方案 

分 类 号：R730.5[医药卫生—肿瘤]