他汀类药物在缺血性脑血管病二级预防中的应用效果及其影响因素  

Application Effect and Influencing Factors of Statins in Secondary Prevention of Ischemic Cerebrovascular Disease

作　　者：孟婷婷 耿德胜 MENG Tingting;GENG Desheng(Department of Pharmacy,The Sixth People's Hospital of Luoyang,Luoyang Henan 471000)

机构地区：[1]洛阳市第六人民医院药剂科,河南洛阳471000 [2]新乡医学院第三附属医院急诊科,河南新乡453003

出　　处：《医学临床研究》2024年第7期1061-1063,1067,共4页Journal of Clinical Research

摘　　要：【目的】探讨他汀类药物在缺血性脑血管病(ICVD)二级预防中的应用效果及其影响因素。【方法】本院收治的109例ICVD患者,随访1年,死亡1例,失访2例,根据是否再次发生ICVD将患者分为复发组和未复发组,比较两组患者的临床资料,探讨影响他汀类药物预防效果的因素。【结果】纳入的106例患者,其中15例(14.15%)ICVD复发,未复发91例(85.85%)。复发组和未复发组的年龄、性别、家族史、吸烟史、饮酒史、白细胞计数、血糖比较,差异均无统计学意义(P>0.05);两组体重指数(BMI)、文化程度、医疗支付方式、合并疾病数量、服用药物种类以及依从性等比较,差异有统计学意义(P<0.05)。多因素回归分析显示,BMI高、文化程度低、自费医疗支付、合并疾病数量多、服用药物种类多以及依从性低是他汀类药物在ICVD二级预防中复发的独立危险因素(P<0.05)。【结论】他汀类药物在ICVD二级预防中的效果受患者BMI、文化程度、医疗支付方式、合并疾病数量、药物种类及依从性等因素影响,优化二级预防需关注上述因素。【Objective】To explore the application effect and influencing factors of statins in the secondary prevention of ischemic cerebrovascular disease(ICVD).【Methods】A total of 109 ICVD patients treated in our hospital were followed up for one year.One patient died,and two were lost to follow-up.Patients were divided into a recurrence group and a non-recurrence group based on whether ICVD recurred.Univariate analysis was used to compare the clinical data of the two groups and to explore the factors affecting the preventive effect of statins.【Results】Among the 106 patients,15 cases(14.15%)had ICVD recurrence,while 91 cases(85.85%)did not have recurrence of ICVD.There were no statistically significant differences in age,gender,family history,smoking history,alcohol consumption history,white blood cell count,and blood glucose levels between the recurrence and non-recurrence groups(P>0.05).However,significant differences were found in body mass index(BMI),educational level,medical payment method,number of comorbidities,types of medications taken,and compliance(P<0.05).Multivariate regression analysis showed that high BMI,low educational level,self-payment for medical expenses,a high number of comorbidities,taking multiple types of medications,and low compliance were independent risk factors for recurrence in the secondary prevention of ICVD with statins(P<0.05).【Conclusion】The effect of statins in the secondary prevention of ICVD is influenced by factors such as patients'BMI,educational level,medical payment method,comorbidities,types of medications,and compliance.Optimizing secondary prevention requires attention to these related factors.

关 键 词：脑缺血 羟甲基戊二酰基CoA还原酶抑制剂/治疗应用 影响因素分析 

分 类 号：R743[医药卫生—神经病学与精神病学]