幽门螺杆菌抗体谱、胃泌素及胃蛋白酶原表达与消化性溃疡的关系分析  

Correlation between expressions of Helicobacter antibody repertoire,gastrin and pepsinogen and pylori peptic ulcer

作　　者：赵雅娟 张彦[1] 郭宝珍[1] 闫旭 李恳 常文龙[3] 李金梅[4] ZHAO Yajuan;ZHANG Yan;GUO Baozhen;YAN Xu;LI Ken;CHANG Wenlong;LI Jinmei(Department of Gastroenterology,Baoding First Central Hospital,Baoding 071000,Hebei,China;Department of Neurology,Baoding First Central Hospital,Baoding 071000,Hebei,China;Department of Laboratory Medicine No.3,Baoding First Central Hospital,Baoding 071000,Hebei,China;Department of Pathology,Baoding First Central Hospital,Baoding 071000,Hebei,China)

机构地区：[1]保定市第一中心医院消化内一科,河北保定071000 [2]保定市第一中心医院神经内五科,河北保定071000 [3]保定市第一中心医院检验三科,河北保定071000 [4]保定市第一中心医院病理科,河北保定071000

出　　处：《西部医学》2024年第8期1223-1227,共5页Medical Journal of West China

基　　金：保定市科技计划项目(2241ZF054)。

摘　　要：目的分析幽门螺杆菌(Hp)抗体谱、胃泌素-17(G-17)及胃蛋白酶原(PG)表达与消化性溃疡的关系。方法回顾性分析2021年4月—2022年4月我院消化内科收治的经消化内镜及病理组织检查确诊为消化性溃疡或胃癌的125例患者的病例资料,其中诊断为消化性溃疡的90例患者纳入消化性溃疡组,诊断为胃癌的35例患者纳入胃癌组,另选取同时期健康体检者50例纳入对照组。比较3组入院时G-17、PGⅠ、PGⅡ水平、Hp抗体谱及Hp阳性率,分析消化性溃疡患者中Hp阳性与Hp阴性患者G-17、PGⅠ、PGⅡ水平差异,绘制受试者工作特征(ROC)曲线评估G-17、PGⅠ、PGⅡ水平对Hp阳性消化性溃疡的诊断效能。结果入院时,消化性溃疡组G-17、PGⅡ水平均明显低于胃癌组,PGⅠ水平明显高于胃癌组(P<0.05);对照组G-17、PGⅡ水平均低于其他两组(P<0.05),PGⅠ水平高于其他两组(P<0.05);消化性溃疡组与胃癌组Hp抗体谱比较差异无统计学意义(P>0.05);消化性溃疡组和胃癌组各抗体阳性率均高于对照组(P<0.05)。90例消化性溃疡患者中Hp阳性67例,35例胃癌患者中Hp阳性31例,消化性溃疡组和胃癌组Hp阳性率比较差异无统计学意义(P>0.05)。消化性溃疡Hp阴性患者G-17、PGⅡ水平均明显低于Hp阳性患者,PGⅠ水平明显高于Hp阳性患者(P<0.05);G-17、PGⅠ、PGⅡ及其联合检测诊断Hp阳性消化性溃疡的曲线下面积(AUC)分别为0.633、0.768、0.761、0.854。结论消化性溃疡患者较胃癌患者G-17、PGⅡ水平下降,PGⅠ水平升高,并且消化性溃疡患者中Hp阳性患者以上指标变化更为显著,可辅助临床诊断胃肠疾病。Objective To analyze the correlation between expressions of Helicobacter antibody repertoire,gastrin-17(G-17)and pepsinogen(PG)and peptic ulcer.Methods The case data of 125 patients who were diagnosed with peptic ulcer or gastric cancer by digestive endoscopy and histopathological examination in department of gastroenterology of the hospital were retrospectively analyzed from April 2021 to April 2022.Among them,90 cases diagnosed with peptic ulcer were included in peptic ulcer group and 35 cases diagnosed with gastric cancer were enrolled as gastric cancer group.Another 50 healthy subjects with physical examination during the same time period were selected as control group.The levels of G-17,PG I and PG II and Hp antibody repertoire and positive rate of Hp were compared among the three groups at admission.The differences in levels of G-17,PG I and PG II between Hp-positive and Hp-negative patients with peptic ulcer were analyzed.Receiver operating characteristic(ROC)curve was drawn to evaluate the diagnostic efficiency of G-17,PG I and PGⅡon Hp-positive peptic ulcer.Results At admission,the levels of G-17 and PGⅡin peptic ulcer group were significantly lower than those in gastric cancer group while the level of PGⅠwas significantly higher than that in gastric cancer group(P<0.05),and the levels of G-17 and PG-Ⅰin control group were lower than those in the other two groups(P<0.05)while the level of PG-Ⅰwas higher than that in the other two groups(P<0.05),and there was no statistical significance in the Hp antibody repertoire between peptic ulcer group and gastric cancer group(P>0.05),and the positive rates of various antibodies in the two groups were higher than those in control group(P<0.05).Among the 90 patients with peptic ulcer,67 cases were positive for Hp,and among the 35 patients with gastric cancer,31 cases were positive for Hp.There was no statistical difference in the positive rate of Hp between the two groups(P>0.05).The levels of G-17 and PGⅡin Hp-negative patients with peptic ulcer were si

关 键 词：抗体谱 胃泌素 胃蛋白酶原 幽门螺杆菌 消化性溃疡 

分 类 号：R573.1[医药卫生—消化系统]