食管癌患者生存随访调查及预后影响因素  

Survival follow-up survey and prognostic factors of esophageal cancer patients

作　　者：郭婷婷 曹燕珍 图荪阿依·吾麦尔 胡佳捷 余帆 杨丽丽 GUO Ting-Ting;CAO Yan-Zhen;TUSUNAYI·Wumaier(Department of Pathology,The Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,Xinjiang,China)

机构地区：[1]新疆医科大学第五附属医院病理科,新疆乌鲁木齐830011 [2]新疆医科大学第三临床医学院附属肿瘤医院病理科

出　　处：《吉林医学》2024年第8期1828-1832,共5页Jilin Medical Journal

基　　金：新疆维吾尔自治区自然科学基金项目[项目编号:2022D01C302]。

摘　　要：目的:分析食管癌患者术后生存情况,研究食管癌患者预后的影响因素。方法:回顾性分析244例食管癌病例的临床资料,通过对术后食管癌患者进行随访,以食管癌患者的死亡为结局,分析食管癌患者的预后情况并进行影响因素分析。结果:研究期间食管癌死亡共142例,患者预后总生存期(OS)中位数为26个月,1年、3年、5年累计存活率分别为69.6%、40.2%、29.4%。单因素分析结果显示,不同食管癌肿瘤的位置、肿瘤浸润的范围、浸润的深度、区域淋巴结数量、是否远处转移、临床分期、淋巴结状态的食管癌患者预后差异有统计学意义(P<0.05);多因素结果显示,肿瘤浸润范围[心率(HR)=3.068,95%CI=1.107~9.253]、淋巴结状态(HR=2.589,95%CI=1.060~6.322)是影响食管癌患者生存预后的独立影响因素。结论:食管癌患者预后较差,肿瘤浸润范围、淋巴结状态是影响食管癌患者生存预后的独立影响因素。Objective To analyze the postoperative survival of patients with esophageal cancer and explore the factors affecting the prognosis of patients with esophageal cancer.Method Retrospective analysis of clinical data from 244 cases of esophageal cancer,followed up with postoperative esophageal cancer patients,and analyzed the prognosis of esophageal cancer patients with mortality as the outcome,as well as the influencing factors.Results A total of 142 patients died of esophageal cancer during the study period.The median survival time was 26 months,and the cumulative survival rates of 1,3 and 5 years were 69.6%,40.2%and 29.4%,respectively.Univariate analysis showed that tumor location,tumor invasion range,invasion depth(T),regional lymph node(N),distant metastasis(M),clinical stage and lymph node status were prognostic factors(P<0.05).Multivariate results showed that tumor invasion range(HR=3.068,95%CI=1.107~9.253)and lymph node status(HR=2.589,95%CI=1.060~6.322)were independent factors affecting the survival and prognosis of patients with esophageal cancer.Conclusion The prognosis of esophageal cancer patients is poor,and the extent of tumor invasion and lymph node status are independent factors affecting the survival prognosis of esophageal cancer patients.

关 键 词：食管癌 预后 影响因素 

分 类 号：R735.1[医药卫生—肿瘤]