血清miR-195与2型糖尿病合并代谢相关脂肪性肝病相关性的研究  

Relationship between serum miR-195 levels in patientss with type 2 diabetes mellitus and metabolic associated fatty liver disease

作　　者：陈倩 权金星[2] 吕亚亚 张洋洋 刘静[2] 刘菊香[2] CHEN Qian;QUAN Jincing;LYU Yaya(The First School of Clinical Medicine,Ningria Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学第一临床医学院,银川750004 [2]甘肃省人民医院内分泌科

出　　处：《中国糖尿病杂志》2024年第7期501-504,共4页Chinese Journal of Diabetes

基　　金：国家自然科学基金(81960160);甘肃省自然科学基金(20JR5RA155);甘肃省人民医院院内科研基金(23GSSYD-15)。

摘　　要：目的 探讨血清mi R-195与T2DM合并代谢相关脂肪性肝病(MAFLD)的相关性。方法 选取2022年10月至2023年8月于甘肃省人民医院内分泌科治疗的T2DM患者79例,根据是否合并MAFLD分为单纯T2DM组(n=37)和合并MAFLD组(MAFLD,n=42),同期选取34名体检健康者为正常对照(NC)组。比较各组生化指标和血清mi R-195表达。结果 与NC组比较,T2DM、MAFLD组FPG、Hb AIc、胰岛素低抗指数(HOMA-IR)升高,HDL-C降低(P<0.05)。MAFLD组TG、超敏C反应蛋白(hs-CRP)高于NC、T2DM组(P<0.05)。NC、T2DM、MAFLD组血清mi R-195表达依次降低(P<0.05),血浆脂肪酸合酶(FAS)依次升高(P<0.05)。Spearman相关分析显示,mi R-195与FPG、HOMA-IR、hs-CRP、FAS呈负相关(P<0.05)。多元线性回归分析显示,HOMA-IR、FAS是血清mi R-195的影响因素。结论 T2DM合并MAFLD患者血清mi R-195表达下调,可能通过糖脂代谢、IR及炎症反应参与T2DM合并MAFLD发生发展。Objective To exploring the correlation between serum miR-195 and metabolic associated fatty liver disease(MAFLD)in type 2 diabetes mellitus(T2DM)patients.Methods A total of 79 patients with T2DM who were treated in the Endocrinology Department of Gansu Provincial People's Hospital were enrolled in this study from October 2022 to August 2023.They were divided into simple T2DM(n=37)and MAFLD group(MAFLD,n=42)according to whether they were complicated with MAFLD.Meanwhile,34 healthy individuals who underwent physical examinations were selected as the normal control(NC)group.Results Compared with the NC group,FPG,HbAc and HOMA-IR increased,while HDL-C decreased in T2DM and MAFLD group(P<0.05).The TG and hs-CRP levels were higher in MAFLD group than in NC and T2DM group(P<0.05).The serum miR-195 expression decreased sequentially(P<0.05),while FAS increased sequentilly in NC,T2DM,and MAFLD group(P<0.05).Spearman correlation analysis showed that miR-195 was negatively correlated with FPG,HOMA-IR,hs-CRP,and FAS(P<0.05).Multiple linear regression analysis showed that HOMA-IR and FAS were the influencing factors for serum miR-195.Conclusions Down-regulation of serum miR-195 expression in patients with T2DM combined with MAFLD may be by glucose and lipid metabolism,IR and inflammatory response.

关 键 词：miR-195 糖尿病 2型 代谢相关脂肪性肝病 胰岛素抵抗 炎症反应 

分 类 号：R575.5[医药卫生—消化系统] R587.1[医药卫生—内科学]