生物基增塑剂异山梨醇二己酸酯的一步酶法合成  

One-step enzymatic synthesis of bio-based plasticizer isosorbide hexanoate diester

作　　者：龙慧仪 周宇洋 朱明新 潘顺龙 周华 LONG Huiyi;ZHOU Yuyang;ZHU Mingxin;PAN Shunlong;ZHOU Hua(School of Environmental Science and Engineering,Nanjing Tech University,Nanjing 211816,Jiangsu,China;College of Biotechnology and Pharmaceutical Engineering,Nanjing Tech University,Nanjing 211816,Jiangsu,China)

机构地区：[1]南京工业大学环境科学与工程学院,江苏南京211816 [2]南京工业大学生物与制药工程学院,江苏南京211816

出　　处：《精细化工》2024年第8期1833-1839,共7页Fine Chemicals

基　　金：江苏省研究生科研与实践创新计划项目(SJCX23_0471)。

摘　　要：以甲苯为溶剂,在4A分子筛存在下,固定化脂肪酶(Novozym 435)催化异山梨醇与正己酸酯化反应制备了异山梨醇二己酸酯。通过单因素实验选择4个因素(反应时间、反应温度、酶添加量、4A分子筛用量)进行了响应面实验分析。结果表明,在甲苯10 mL、异山梨醇3 mmol、n(异山梨醇)∶n(正己酸)=1∶6、反应时间43 h、反应温度40℃、Novozym 435添加量0.10 g、4A分子筛用量为2.00 g的最优条件下,异山梨醇二己酸酯的产率达到了93.77%。Isosorbide dihexanoate was prepared from the esterification reaction of isosorbide and hexanoic acid under the catalysis of immobilized lipase Novozym 435 in the presence of 4A molecular sieve using toluene as solvent.Response surface analysis was then conducted with four factors(reaction time,reaction temperature,enzyme addition amount,4A molecular sieve dosage)selected via single factor experiment.The results showed that the yield of isosorbide dihexanoate reached 93.77%under the optimal conditions of toluene 10 mL,isosorbide 3 mmol,n(isosorbide)∶n(caproic acid)=1∶6,reaction time 43 h,reaction temperature 40℃,Novozym 4350.10 g and 4A molecular sieve 2.00 g.

关 键 词：异山梨醇酯 脂肪酶 酯化反应 响应面法 催化技术 

分 类 号：TQ414[化学工程]