Tuning the diffusion constant to optimize the readout of positional information of spatial concentration patterns  

作　　者：江嘉杰 罗春雄 刘峰 Ka Kit Kong;Chunxiong Luo;Feng Liu(The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics,School of Physics,Peking University,Beijing 100871,China;Center for Quantitative Biology,Peking University,Beijing 100871,China;Wenzhou Institute University of Chinese Academy of Sciences,Wenzhou 325001,China;Key Laboratory of Hebei Province for Molecular Biophysics,Institute of Biophysics,School of Health Science&Biomedical Engineering,Hebei University of Technology,Tianjin 300130,China)

机构地区：[1]The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics,School of Physics,Peking University,Beijing 100871,China [2]Center for Quantitative Biology,Peking University,Beijing 100871,China [3]Wenzhou Institute University of Chinese Academy of Sciences,Wenzhou 325001,China [4]Key Laboratory of Hebei Province for Molecular Biophysics,Institute of Biophysics,School of Health Science&Biomedical Engineering,Hebei University of Technology,Tianjin 300130,China

出　　处：《Chinese Physics B》2024年第8期579-586,共8页中国物理B（英文版）

基　　金：Project supported by the National Natural Science Foundation of China (Grant Nos.32271293 and 11875076)。

摘　　要：Positional information encoded in spatial concentration patterns is crucial for the development of multicellular organisms.However,it is still unclear how such information is affected by the physically dissipative diffusion process.Here we study one-dimensional patterning systems with analytical derivation and numerical simulations.We find that the diffusion constant of the patterning molecules exhibits a nonmonotonic effect on the readout of the positional information from the concentration patterns.Specifically,there exists an optimal diffusion constant that maximizes the positional information.Moreover,we find that the energy dissipation due to the physical diffusion imposes a fundamental upper limit on the positional information.

关 键 词：pattern formation positional information mutual information DIFFUSION 

分 类 号：Q2-3[生物学—细胞生物学] O29[理学—应用数学]