抑郁症快感缺失发病机制研究进展  

Research Progress on the Pathogenesis of Anhedonia in Depression

作　　者：王薇[1] 聂昭雯 刘忠纯[1,2] WANG Wei;NIE Shaowen;LIU Zhongchun(Mental Health Center,Renmin Hospital of Wuhan University,Wuhan 430060,China;Taikang Life Medical Center,Wuhan University,Wuhan 430071,China)

机构地区：[1]武汉大学人民医院精神卫生中心,武汉430060 [2]武汉大学泰康生命医学中心,武汉430071

出　　处：《神经损伤与功能重建》2024年第8期462-465,共4页Neural Injury and Functional Reconstruction

基　　金：国家自然科学基金联合基金重点项目(No.U21A20364);国家重点研发计划(No.2018YFC1314600)。

摘　　要：快感缺失是抑郁症的核心症状之一,也是抑郁症治疗中的难点,是抑郁症患者出现病程长、生活质量大幅下降、社会功能严重受损的重要预测因子之一。当前国内外对抑郁症快感缺失表型的研究为探索其发生发展机制提供了重要信息,但仍未建立一个完整可靠的病因网络,这使得研发针对性的靶向治疗方案受到局限。因此,探索抑郁症快感缺失表型的病因对临床治疗具有重要的意义。现对既往有关抑郁症快感缺失的文献进行总结,从社会心理因素、生理生化因素、脑影像及神经环路与基因遗传等方面介绍抑郁症快感缺失的发病机制研究进展。Anhedonia is one of the core symptoms of depression,and it is also a difficult point in the treatment of depression.It is one of the important predictors for patients with long-term course,significant decline in quality of life and severe impairment of social function.Current research on the anhedonia phenotype of depression has provided important information for exploring the mechanism of its occurrence and development,but a complete and reliable etiological network has not yet been established,which limits the development of targeted therapy.Therefore,exploring the etiology of anhedonia phenotype in depression is of great significance for clinical treatment.This review summarizes the previous literature on anhedonia in depression,and introduces the research progress on the pathogenesis from the aspects of social psychological factors,physiological and biochemical factors,brain imaging,neural circuits and genetic inheritance.

关 键 词：抑郁症 快感缺失 发病机制 神经环路 基因遗传 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学] R749