周围神经修复中雪旺细胞与巨噬细胞的交互作用  

Interaction between Schwann Cells and Macrophages in Peripheral Nerve Repair

作　　者：秦欢 支金草 郭孝静 王淑瑾 张博[1] 裴飞[2] 王艳[2] QIN Huan;ZHI Jincao;GUO Xiaojing;WANG Shujin;ZHANG Bo;PEI Fei;WANG Yan(Heilongjiang University of Chinese Medicine,Harbin 150006,China;The Second Hospital Affiliated to Heilongjiang University of Chinese Medicine,Harbin 150001,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150006 [2]黑龙江中医药大学附属第二医院康复中心,哈尔滨150001

出　　处：《神经损伤与功能重建》2024年第8期483-487,共5页Neural Injury and Functional Reconstruction

基　　金：国家自然科学基金项目(夹脊电针结合跑台训练对坐骨神经损伤大鼠胫骨重建及NGF-TrkA与Wnt/β-catenin信号通道的影响,No.81973926);国家自然科学基金项目(基于脾主四肢肌肉理论探讨针刺脾经俞募穴结合跑台训练对失神经肌萎缩影响的实验研究,No.82274623);黑龙江省自然科学基金项目(夹脊电针结合感觉训练对坐骨神经损伤大鼠感觉轴突再生的影响机制,No.LH2021H090)。

摘　　要：周围神经系统是覆盖全身的神经网络,但也因其分布广泛而更易受到损伤,随着周围神经损伤发病率的逐年增高,神经损伤后再生与修复已成为各类神经科学的研究重点。周围神经的再生机制与多种细胞种群有关,特别是雪旺细胞(Schwann cells,SCs)和巨噬细胞,它们是周围神经内包含最重要的两类细胞,参与周围神经生长、修复、重建的各个过程,并从炎症反应、细胞碎片清除、营养支持、轴突再生等方面促进神经损伤的修复。本文分别从SCs和巨噬细胞在周围神经再生修复过程中的作用及二者的交互作用等方面进行综述,以期为周围神经损伤的基础和临床研究提供新思路。The peripheral nervous system is a neural network that covers the entire body,but its widespread distribution makes it more susceptible to injury.With the annual increase in the incidence of peripheral nerve damage,regeneration and repair of nerve after injury have become the focus of various neuroscience research.The regeneration mechanism of the peripheral nerves is related to multiple cell populations,especially Schwann cells(SCs)and macrophages.These are the two most important types of cells within the peripheral nerves,involved in the growth,repair,and reconstruction processes of the peripheral nerves.They promote the repair of nerve injuries through various aspects such as inflammatory response,cellular debris clearance,nutritional support,and axonal regeneration.This article provides an overview of the roles of SCs and macrophages in the regeneration and repair process of peripheral nerves,as well as their interactions,in order to offer new insights for basic and clinical research on peripheral nerve injuries.

关 键 词：周围神经 雪旺细胞 巨噬细胞 轴突 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学] R745