槲皮素-3-O-乙酸-(4-(3H-1,2-二硫杂环戊烯-3-硫酮))-苯酯的合成  

Synthesis of quercetin-3-O-acetic acid-(4-(3H-1,2-dithiacyclopentene-3-thione))-phenyl ester

作　　者：何世波 肖智心 刘建 刘明星 HE Shibo;XIAO Zhixin;LIU Jian;LIU Mingxing(School of Biological Engin.and Food,Hubei Univ.of Tech.,Wuhan 430068,China)

机构地区：[1]湖北工业大学生物工程与食品学院,湖北武汉430068

出　　处：《湖北工业大学学报》2024年第4期37-40,56,共5页Journal of Hubei University of Technology

基　　金：国家级大学生创新创业训练计划项目(202110500010)。

摘　　要：以芦丁为起始原料,以5-(4-羟基苯基)-3H-1,2-二硫杂环戊烯-3-硫酮作为H_(2)S供体,合成一种具有治疗糖尿病且促进伤口愈合功能的药物槲皮素-3-O-乙酸-(4-(3H-1,2-二硫杂环戊烯-3-硫酮))-苯酯。整个工艺路线包括取代、水解、williamson醚化、水解和酯化等5步反应,总产率为6.4%。各步产物经MS、^(1)H NMR分析表征。该合成路线具有原料廉价易得、反应条件温和、操作简便的优点。A drug quercetin-3-O-acetic acid-(4-(3H-1,2-dithiacyclopentene-3-thione))-phenyl ester with the function of treating diabetes and promoting wound healing was synthesized by using rutin as the starting material and 5-(4-hydroxyphenyl)-3H-1,2-dithiacyclopentene-3-thione as the H_(2)S donor.The whole process route included a total of five reaction steps including substitution,hydrolysis,williamson etherification,hydrolysis,and esterification,with a total yield of 6.4%.The products of each step were characterized by MS and ^(1)H NMR analysis.The synthetic route has the advantages of cheap and easy availability of raw materials,mild reaction conditions and simple operation.

关 键 词：芦丁 槲皮素 H_(2)S供体 

分 类 号：R914.4[医药卫生—药物化学]