双向固体发酵应用于中药的研究进展  

Research progress on bidirectional solid fermentation applied to traditional Chinese medicine

作　　者：李莉[1] 马佳荣 王玉辉 赵敏[1] 杨锡仓 李芸[1] LI Li;MA Jiarong;WANG Yuhui;ZHAO Min;YANG Xicang;LI Yun(Northwest Collaborative Innovation Center for TCM,Gansu Pharmaceutical Industry Innovation Research Institute,Gansu University of Chinese Medicine,Lanzhou,Gansu,730000 P.R.China;Yang Xicang National Famous TCM Expert Inheritance Studio,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou,Gansu,730000 P.R.China)

机构地区：[1]甘肃中医药大学陇药产业创新研究院,西北中藏药省部共建协同创新中心,甘肃兰州730000 [2]甘肃中医药大学附属医院,杨锡仓全国名老中医药专家传承工作室,甘肃兰州730000

出　　处：《华西药学杂志》2024年第4期483-487,共5页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(批准号:82360773);甘肃省中药炮制技术传承基地建设项目(2022)。

摘　　要：发酵作为常用的中药炮制技术之一,是指在一定条件下借助微生物和酶的催化分解作用,改变原有药性、药效的方法。现系统综述双向固体发酵技术的现状、常用的发酵菌种、发酵前后对中药毒性及药效成分的影响,并对中药发酵的发展方向提出了建议,可为后续深入研究和开发利用中药发酵技术提供参考。Fermentation is a commonly used processing technology employed in traditional Chinese medicine.It involves the alteration of an original substance's properties and efficacy through the action of microorganisms and enzymes.This paper presents a comprehensive review of the current state of knowledge regarding bidirectional solid fermentation technology,common fermentation strains,and the effects of fermentation on the toxicity and pharmacodynamic components of traditional Chinese medicine.Additionally,it outlines potential avenues for the development of traditional Chinese medicine fermentation technology and provides suggestions for future research and development.This review may serve as a valuable references for those engaged in the scientific investigation of traditional Chinese medicine fermentation technology.

关 键 词：双向固体发酵 中药 发酵菌种 活性成分 毒性 药效 综述 

分 类 号：R28[医药卫生—中药学]