颅内外动脉弯曲与急性缺血性脑血管病发生的研究进展  

Research Progress on the Relationship between Intracranial and Extracranial Arterial Tortuosity and Acute Cerebral Ischemic

作　　者：黎莉[1] 李长清[1] LI Li;LI Chang-qing(Department of Neurology,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)

机构地区：[1]重庆医科大学附属第二医院神经内科,重庆400010

出　　处：《中国临床神经科学》2024年第3期344-350,共7页Chinese Journal of Clinical Neurosciences

摘　　要：在全球范围内,急性缺血性脑卒中(AIS)是造成死亡与残疾的第三大主要原因,除了常见的脑血管危险因素外,近几年研究发现颅内外动脉血管弯曲可能与AIS/短暂性脑缺血发作(TIA)存在潜在联系。文中阐述了动脉弯曲的概念、评估方法及其与急性脑缺血(ACI)的关系,从血流动力学(血管壁剪切应力、血栓栓塞形成、低灌注)、机械牵拉及压迫作用方面分析了动脉弯曲在ACI发生中的作用机制,并概述了伴有严重动脉弯曲ACI患者的防治策略,通过抗血小板治疗、静脉溶栓和手术的干预方式可能有效。认识颅内外动脉弯曲对于ACI的预防、治疗具有重要意义。Acute ischemic stroke(AIS)is the third leading cause of death and disability globally.In addition to common cerebrovascular risk factors,recent studies have found that intracranial and extracranial arterial tortuosity may have a potential link with AIS/TIA(transient ischemic attack).The concept and evaluation methods of arterial tortuosity,as well as its relationship with acute cerebral ischemic(ACI)were elaborated.The mechanism of arterial tortuosity in the occurrence of ACI from the perspectives of hemodynamics(wall shear stress,thromboembolism,low perfusion),mechanical traction and compression was analyzed.The prevention and treatment strategies for ACI patients with severe arterial tortuosity were outlined,which may be effective through antiplatelet therapy,intravenous thrombolysis and surgery.Understanding the tortuosity of intracranial and extracranial arteries is of great significance for the prevention and treatment of ACI.

关 键 词：动脉弯曲 弯曲指数 发生机制 急性缺血性脑卒中 急性脑缺血 

分 类 号：R743[医药卫生—神经病学与精神病学]