不良生活方式与慢性肾脏疾病的孟德尔随机化研究  

Mendelian randomization study of unhealthy lifestyle and chronic kidney disease

作　　者：李桦 钟禹文 罗浩 粟宏伟 LI Hua;ZHONG Yu-wen;LUO Hao;SU Hong-wei(College of Integrated Chinese and Western Medicine,Southwest Medical University,Luzhou,Sichuan 646000,China;不详)

机构地区：[1]西南医科大学中西医结合学院,四川泸州646000 [2]西南医科大学附属中医医院泌尿外科,四川泸州646000

出　　处：《现代预防医学》2024年第15期2808-2812,2823,共6页Modern Preventive Medicine

基　　金：四川省科学技术计划项目重大科技专项(2022YFS0621)。

摘　　要：目的利用孟德尔随机化(Mendelian randomization,MR)分析7种常见不良生活方式(吸烟、饮酒、糖消耗、添加盐的消耗、脂肪摄入、睡眠不足、工作中的久坐行为)与慢性肾脏疾病(chronic kidney disease,CKD)之间潜在的因果关系。方法本研究通过全基因组关联分析(genome-wide association,GWAS)数据库获得工具变量,将逆方差加权(inverse-variance weighted,IVW)作为主要分析方法,MR-Egger回归和加权中位数(weighted-median,WM)作为补充方法分析暴露对结局的潜在因果关系,并对结果进行敏感性分析。结果IVW分析结果显示脂肪摄入(OR:1.09,95%CI:1.01~1.19,P=0.027)与CKD有因果关系,敏感性分析结果未发现有显著的异质性(Q=18.00,P=0.12)或多效性(P=0.27);吸烟、饮酒、糖消耗、添加盐的消耗、睡眠不足及工作中的久坐行为与慢性肾脏疾病IVW分析结果的P值均无统计学意义。结论脂肪摄入与CKD之间存在正相关风险关系,建议控制脂肪摄入量降低CKD发病风险。Objective To investigate the potential causal relationship between seven common unhealthy lifestyles(smoking,alcohol,sugar intake,salt intake,fat intake,sleep,and prolonged sedentary behaviors)and chronic kidney disease(CKD)using Mendelian randomization(MR)method.Methods The instrumental variables were obtained from genome-wide association study(GWAS)databases.Inverse-variance weighted(IVW)method was used as the primary analysis method,and MR-Egger and weighted-median(WM)as supplementary methods to analyze the potential causal association between exposure and outcome.Sensitivity analyses were also conducted.Results The IVW analysis showed a causal relationship between fat intake(OR=1.09,95%CI:1.01-1.19,P=0.027)and CKD.Sensitivity analysis results did not reveal notable heterogeneity(Q=18.00,P=0.12)or pleiotropy(P=0.27).Smoking,alcohol,sugar intake,salt intake,sleep,and prolonged sedentary behaviors showed no causal relationship with CKD in the IVW analysis.Conclusion There is a positive relationship between fat intake and CKD risk.It is suggested to control fat intake to reduce the risk of CKD.

关 键 词：孟德尔随机化 不良生活方式 慢性肾脏疾病 全基因组关联分析 脂肪摄入 

分 类 号：R692[医药卫生—泌尿科学]