基于网络药理学探究中药治疗抽动障碍作用机制的研究进展  

Research progress in the mechanism of Chinese medicine in the treatment of tic disorders based on network pharmacology

作　　者：钟明秀 张迪 刘英[2] ZHONG Mingxiu;ZHANG Di;LIU Ying(Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine,Nanchang 330006,China)

机构地区：[1]江西中医药大学,南昌330004 [2]江西中医药大学附属医院儿科,南昌330006

出　　处：《中国中西医结合儿科学》2024年第4期305-308,共4页Chinese Pediatrics of Integrated Traditional and Western Medicine

基　　金：江西省中医药管理局科技计划项目(2023B1239);江西省教育厅科学技术研究项目(GJJ2200983);江西省中医药管理局科技计划项目(2022B509);江西省卫生健康委科技计划项目(202310696)。

摘　　要：随着社会的发展及环境的影响,近年来,抽动障碍的发病率呈逐年增长趋势,成为目前临床中较为常见的儿科疾病之一。西医针对抽动障碍的治疗,主要以多巴胺类、中枢性α2受体激动剂等药物为主,同时配合心理治疗,具有一定的疗效,但其不良反应使部分儿童不能耐受。中医药立足于整体观念和辨证论治,在抽动障碍的防治中安全性和疗效都具有更明显的优势。中药中单味药、药对和复方都具有多靶点、多通路的调节作用,其与现代理论网络药理学的核心思想一致,所以,网络药理学方法正逐渐地被中医药研究其作用机制所接纳及采用。本文就网络药理学在中药治疗抽动障碍作用机制的相关研究应用进展进行综述,以及对研究中存在的问题进行阐述,以期为网络药理学在中药治疗抽动障碍研究的应用提供参考。With the development of society and the influence of the environment,the incidence of tic disorders(TD)has increased year by year in recent years,and it has become one of the more common pediatric diseases in clinical practice.The treatment for TD in western medicine is mainly based on dopamine(DA)and centralα2 receptor agonists,combined with psychotherapy,which has certain efficacy,but its adverse reactions make some children intolerant.The holistic concept and treatment based on syndrome differentiation in traditional Chinese medicine have significant advantages in safety and efficacy in the prevention and treatment of TD.Single herbs,drug pairs and compounds in traditional Chinese medicine have multi-target and multi-pathway regulatory effects,which are consistent with the core idea of network pharmacology in modern theory.Therefore,network pharmacology methods are gradually being accepted and adopted by traditional Chinese medicine to study its mechanism of action.This paper reviews the research and application progress of network pharmacology in the mechanism of action of traditional Chinese medicine in the treatment of TD,and expounds the existing problems in the research,in order to provide reference for the application of network pharmacology in the research of traditional Chinese medicine in the treatment of TD.

关 键 词：抽动障碍 网络药理学 中药 研究进展 儿童 

分 类 号：R748[医药卫生—神经病学与精神病学]