TIgE、SIgE与梅尼埃病患者前庭功能损害的相关性  

Correlation Between TIgE,SIgE and Vestibular Impairment in Patients with Meniere’s Disease

作　　者：王季 张建 王凯 WANG Ji;ZHANG Jian;WANG Kai(Department of Otorhinolaryngology,Nanshi Hospital of Nanyang,Nanyang 473000,China)

机构地区：[1]南阳南石医院耳鼻喉科,河南南阳473000

出　　处：《河南医学研究》2024年第15期2804-2808,共5页Henan Medical Research

摘　　要：目的分析血清总免疫球蛋白E(TIgE)、特异性免疫球蛋白E(SIgE)与梅尼埃病患者前庭功能的相关性。方法将2021年3月至2023年2月门诊收治的67例梅尼埃病患者为观察组,同期50例入院体检健康者为对照组,检测两组血清TIgE、SIgE,以及纯音听阈、前庭功能检查[冷热双温试验、眼肌前庭诱发肌源性电位(oVEMP)、颈肌诱发肌源性电位(cVEMP)]。用Pearson相关性分析血清TIgE、SIgE的相关性。以ROC曲线评估血清TIgE、SIgE预测梅尼埃病耳聋的价值。结果两组血清TIgE、SIgE水平比较,观察组血清TIgE、SIgE水平均高于对照组,差异有统计学意义(P<0.05);观察组平均纯音听阈值高于对照组(P<0.05);梅尼埃病不同耳聋程度患者血清TIgE、SIgE水平、前庭功能减数电位值、oVEMP电位值、cVEMP电位值比较:正常<轻度<中度<重度,差异有统计学意义(P<0.05);Pearon相关分析显示:梅尼埃病患者血清TIgE与耳聋不同程度、前庭功能减数电位值、oVEMP电位值、cVEMP电位值呈正相关(r=0.809,0.643,0.513,0.677,P<0.001);SIgE和耳聋程度、前庭功能减数电位值、oVEMP电位值、cVEMP电位值呈正相关(r=0.839,0.702,0.429,0.699,P<0.001);经ROC曲线分析,血清TIgE、SIgE、TIgE与SIgE联合检测预测梅尼埃病耳聋程度敏感性、特异性较高,曲线下面积分别为0.939、0.913、0.982。结论血清TIgE、SIgE和梅尼埃病患者的前庭功能具有相关性,且单独检测或联合检测对梅尼埃病耳聋的发生具有预测价值。Objective To analyze the correlation of total serum immunoglobulin E(TIgE),specific immunoglobulin E(SIgE)and vestibular function in patients with Meniere’s disease.Methods In March 2021 to February 2023 at the records of 67 patients with Meniere’s disease of outpatient as observation group,50 cases admitted to hospital medical healthy subjects as control group during this period,the detection of two groups of serum TIgE,SIgE,and pure tone hearing threshold and vestibular function examination[cold hot dual temperature test,ocular vestibular evoked myogenic potentials(oVEMP),cervical vestibular evoked myogenic potentials(cVEMP)muscle origin].The correlation of serum TIgE,SIgE was analyzed by Pearson’s correlation.The value of serum TIgE and SIgE in predicting deafness was evaluated by ROC curve for Meniere’s disease.Results Compared with the serum TIgE and SIgE levels of the two groups,the serum TIgE and SIgE levels of the observation group were higher than that of the control group(P<0.05).Average pure tone hearing threshold value of observation group was obviously higher than that of control group(P<0.05).Comparison of serum TIgE,SIgE level,vestibular function subtraction potential,oVEMP potential,and cVEMP potential in patients with different deafness levels of Meniere’s disease:normal<mild<moderate<severe(P<0.05).Pearson correlation analysis showed that Meniere’s disease patients serum TIgE and the degree of the deaf,the reduction potential of vestibular function value,oVEMP potential value,cVEMP potential value,all were positively correlated(r=0.809,0.643,0.513,0.677,P<0.001).SIgE and deafness,vestibular function reduction potential value,oVEMP potential value,cVEMP potential values were positively correlated(r=0.839,0.702,0.429,0.699,P<0.001).According to ROC curve analysis,the combined detection of serum TIgE,SIgE,TIgE and SIgE predicted high sensitivity and specificity of deafness in Meniere’s disease,and the area under the curve were 0.939,0.913 and 0.982,respectively.Conclusion Serum TIgE,S

关 键 词：梅尼埃病 血清总免疫球蛋白E 特异性免疫球蛋白E 前庭功能 

分 类 号：R741[医药卫生—神经病学与精神病学]