八珍汤加减辅助对鼻咽癌鼻内镜下鼻咽扩大切除术后放疗患者临床疗效及免疫指标的影响  

Effects of Modified Bazhen Decoction on Clinical Efficacy and Immune Indexes of Patients Undergoing Extended Endoscopic Resection for Nasopharyngeal Carcinoma and Postoperative Radiotherapy

作　　者：柳淑洪[1] 彭军[1] 唐立滨[1] 刘春秋[2] 张立杰[1] LIU Shuhong;PENG Jun;TANG Libin;LIU Chunqiu;ZHANG Lijie(Department of Otolaryngology Head and Neck Surgery,Tangshan People's Hospital,Tangshan,Hebei 063000,China;Department of Integrated Traditional Chinese and Western Medicine Oncology,Tangshan People's Hospital,Tangshan,Hebei 063000,China)

机构地区：[1]唐山市人民医院耳鼻咽喉头颈外科,河北唐山063000 [2]唐山市人民医院中西医结合肿瘤科,河北唐山063000

出　　处：《临床误诊误治》2024年第13期91-94,100,共5页Clinical Misdiagnosis & Mistherapy

基　　金：河北省卫健委科研立项基金(20241591)。

摘　　要：目的观察八珍汤加减辅助对鼻咽癌(NPC)鼻内镜下鼻咽扩大切除术后放疗患者临床疗效及免疫指标的影响。方法选取2022年5月至2024年1月行鼻内镜下鼻咽扩大切除术的NPC患者94例作为研究对象,随机数字表法分为对照组和观察组,每组47例。所有患者行术后放疗,对照组给予放疗后常规营养干预和不良反应处理,观察组在对照组的基础上加服八珍汤加减。比较2组临床疗效、唾液分泌功能、疼痛程度、免疫功能及生活质量,并观察不良反应。结果观察组客观缓解率82.89%(39/47)较对照组63.83%(30/47)高(P<0.05)。治疗后,观察组唾液腺分泌指数、鼻咽癌生存质量量表评分、CD3+和CD4+/CD8+水平较对照组高(P<0.05),观察组疼痛视觉模拟评分量表评分、CD8+水平较对照组低(P<0.05)。观察组血小板/白细胞减少、口腔黏膜炎发生率较对照组低(P<0.05)。结论八珍汤加减能改善NPC鼻内镜下鼻咽扩大切除术后放疗患者的放疗效果,缓解疼痛,提高唾液分泌功能,还能够调节免疫功能,减轻不良反应,起到增效减毒的作用。Objective To observe the effects of modified Bazhen decoction on clinical efficacy and immune indexes of patients undergoing extended endoscopic resection for nasopharyngeal carcinoma(NPC)and postoperative radiotherapy.Methods In total,94 NPC patients who underwent extended endoscopic resection for NPC from May 2022 to January 2024 were selected as the research subjects,and were divided into control group(n=47)and observation group(n=47)by random number table method.All patients underwent postoperative radiotherapy.The control group was given conventional nutritional intervention after radiotherapy and treatment of adverse reactions.The observation group was given modified Bazhen decoction on the basis of control group.The clinical efficacy,salivary function,pain degree,immune function and quality of life of the two groups were compared,and the adverse reactions were observed.Results The objective remission rate in the observation group was 82.89%(39/47),which was higher than that in the control group[63.83%(30/47)](P<0.05).After treatment,the salivary gland secretion index,nasopharyngeal cancer quality of life scale score,CD3+and CD4+/CD8+levels in the observation group were higher than those in the control group(P<0.05),while the visual analogue scale pain score and CD8+levels in the observation group were lower than those in the control group(P<0.05).The incidence of platelet/leukopenia and oral mucositis in the observation group was lower than that in the control group(P<0.05).Conclusion Modified Bazhen decoction can improve the radiotherapy effect of NPC patients undergoing extended endoscopic resection for NPC and postoperative radiotherapy,relieve pain,improve salivary secretion function,regulate immune function,and reduce adverse reactions,thus playing a role in enhancing efficacy and reducing toxicity.

关 键 词：鼻咽癌 鼻咽扩大切除术 鼻内镜 放疗 八珍汤 免疫功能 疼痛 不良反应 

分 类 号：R739.63[医药卫生—肿瘤]