晚发性抑郁症患者抑郁程度与多导睡眠参数及疲劳水平的相关性  

The correlation between the degree of depression and polysomnography parameters and fatigue level in patients with late-onset depression

作　　者：郑吉锋 冯彩琴 ZHENG Jifeng;FENG Caiqin(Department of Psychosomatic Disorders(Second Ward of Sleep),Shaoxing Seventh People's Hospital,Shaoxing,Zhejiang 312000,China)

机构地区：[1]绍兴市第七人民医院心身障碍科(睡眠二病区),浙江绍兴312000

出　　处：《中华全科医学》2024年第8期1347-1349,1419,共4页Chinese Journal of General Practice

基　　金：浙江省医药卫生科技计划项目(2023RC292)。

摘　　要：目的比较晚发性抑郁症患者与非抑郁症老年患者多导睡眠参数及疲劳水平差异,并进一步对晚发性抑郁症患者抑郁程度与睡眠质量、结构以及疲劳水平的相关性进行评估。方法以绍兴市第七人民医院2020年3月—2023年3月间收治的晚发性抑郁症患者52例作为研究组,并选取同期非抑郁症老年患者67例作为对照组。比较组间多导睡眠参数水平以及疲劳水平。评估晚发性抑郁症患者抑郁程度与多导睡眠参数及疲劳水平的相关性。结果研究组患者睡眠效率(SE)、N2期百分比(N2%)、慢波睡眠期百分比(SWS%)低于对照组(P<0.05);研究组匹茨堡睡眠质量指数(PSQI)、睡眠潜伏期(SL)、微觉醒指数(MAI)、疲劳严重程度量表(FSS)评分、N1期百分比(N1%)、眼球快速运动睡眠百分比(REM%)、眼球快速运动睡眠(REM)活动度、强度以及密度高于对照组(P<0.05)。相关性分析显示,SE、N2%与患者抑郁程度呈负相关关系,r_(s)分别为-0.869和-0.734;其他指标均与患者抑郁程度呈正相关关系,分别为PQSI评分(r_(s)=0.786)、SL(r_(s)=0.649)、MAI(r_(s)=0.714)、FSS评分(r_(s)=0.738)、N1%(r_(s)=0.687)、SWS%(r_(s)=0.608)、REM%(r_(s)=0.708)、REM活动度(r_(s)=0.815)、REM强度(r_(s)=0.837)和REM密度(r_(s)=0.707)。结论晚发性抑郁症患者睡眠质量下降,睡眠结构紊乱,疲劳感加重,且与患者抑郁程度呈线性相关关系。Objective The differences in polysomnography parameters and fatigue levels were compared between patients with late-onset depression and non-depressed elderly patients,and the correlation between the degree of depression and sleep quality,structure and fatigue level in patients with late-onset depression was further evaluated.Methods A total of 52 patients with late-onset depression admitted to Shaoxing Seventh People's Hospital from March 2020 to March 2023 were selected as the study group,and 67 elderly patients without depression during the same period were selected as the control group.The levels of polysomnography parameters and fatigue were compared between groups.Additionally,the correlation between the degree of depression and polysomnography parameters as well as fatigue level in patients with late-onset depression was evaluated.Results The sleep efficiency(SE),percentage of N2 phase(N2%)and percentage of slow wave sleep(SWS%)in the study group were lower than those in the control group(P<0.05).The Pittsburgh sleep quality index(PSQI),sleep latency(SL),micro-arousal index(MAI),fatigue severity scale(FSS),percentage of N1 phase(N1%),percentage of rapid eye movement sleep(REM%),activity,intensity and density of rapid eye movement sleep(REM)in the study group were higher than those in the control group(P<0.05).Correlation analysis showed that SE and N2%were negatively correlated with the degree of depression in patients,r_(s)=-0.869 and-0.734,respectively.Other indicators were positively correlated with the degree of depression in patients,which were PQSI score(r_(s)=0.786),SL(r_(s)=0.649),AMI(r_(s)=0.714),FSS score(r_(s)=0.738),N1%(r_(s)=0.687),SWS%(r_(s)=0.608),REM%(r_(s)=0.708),REM activity(r_(s)=0.815),REM intensity(r_(s)=0.837)and REM density(r_(s)=0.707).Conclusion The sleep quality of patients with late-onset depression is decreased,accompanied by disrupted sleep structure and aggravated fatigue,exhibiting a linear correlation with the degree of depression.

关 键 词：晚发性抑郁 多导睡眠参数 抑郁程度 疲劳水平 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R163[医药卫生—临床医学]