血清NSE、CYFRA21-1及Pro-GRP与肺癌病理特征及转移的关系  

The Relationship Between Serum NSE,CYFRA21-1,and Pro GRP with Pathological Characteristics and Metastasis of Lung Cancer

作　　者：侯卫科[1] HOU Weike(Henan Hongli Hospital,Changyuan,453400)

机构地区：[1]河南宏力医院,453400

出　　处：《实用癌症杂志》2024年第9期1446-1449,共4页The Practical Journal of Cancer

摘　　要：目的探讨血清神经元特异性烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)及胃泌素释放肽前体(Pro-GRP)与肺癌病理特征及转移的关系。方法选择100例肺癌患者设为肺癌组,50例肺部良性病变患者设为良性组和50例健康体检者设为对照组,采集3组受检者空腹静脉血5 mL,测定血清NSE、Pro-GRP、CYFRA21-1水平。对比3组NSE、Pro-GRP、CYFRA21-1水平差异,并分析NSE、Pro-GRP、CYFRA21-1与肺癌病理特征及转移的关系。结果肺癌组、良性组NSE、Pro-GRP、CYFRA21-1水平均高于对照组,有统计学差异(P<0.05)。肺癌Ⅲ~Ⅳ期者NSE、Pro-GRP、CYFRA21-1水平高于Ⅰ~Ⅱ期者,有统计学差异(P<0.05);小细胞癌NSE、Pro-GRP水平高于腺癌、鳞癌,CYFRA21-1水平低于腺癌,鳞癌Pro-GRP水平高于腺癌,CYFRA21-1水平低于腺癌,有统计学差异(P<0.05);有转移者NSE、Pro-GRP、CYFRA21-1水平均高于无转移者,有统计学差异(P<0.05)。结论肺癌患者NSE、Pro-GRP、CYFRA21-1呈高表达,其水平高低与TNM分期和转移有关。Objective To explore the relationship between serum neuron specific enolase(NSE),cytokeratin 19 fragment(CYFRA21-1),and gastrin releasing peptide precursor(Pro GRP)with pathological characteristics and metastasis of lung cancer.Methods 100 lung cancer patients were selected as the lung cancer group,50 patients with benign lung lesions were selected as the benign group,and 50 healthy individuals were selected as the control group.5 mL of fasting venous blood was collected from 3 groups of subjects,and serum NSE,Pro GRP,and CYFRA21-1 levels were measured.Compare the differences in NSE,Pro GRP,and CYFRA21-1 levels among three groups,and analyze the relationship between NSE,Pro GRP,and CYFRA21-1 with the pathological characteristics and metastasis of lung cancer.Results The levels of NSE,Pro GRP,and CYFRA21-1 in the lung cancer group and benign group were higher than those in the control group,with statistical differences(P<0.05).The levels of NSE,Pro GRP,and CYFRA21-1 in stageⅢ~Ⅳlung cancer patients were higher than those in stageⅠ~Ⅱpatients,with statistical differences(P<0.05);The NSE and Pro GRP levels in small cell carcinoma were higher than those in adenocarcinoma and squamous cell carcinoma,while CYFRA21-1 levels were lower than those in adenocarcinoma.Pro GRP levels in squamous cell carcinoma were higher than those in adenocarcinoma,and CYFRA21-1 levels were lower than those in adenocarcinoma,with statistical differences(P<0.05);The levels of NSE,Pro GRP,and CYFRA21-1 in patients with metastasis were higher than those without metastasis,with statistical differences(P<0.05).Conclusion NSE,Pro GRP,and CYFRA21-1 are highly expressed in lung cancer patients,and their levels are related to TNM staging and metastasis.

关 键 词：肺癌 神经元特异性烯醇化酶 病理特征 细胞角蛋白19片段 胃泌素释放肽前体 转移 

分 类 号：R734.2[医药卫生—肿瘤]