CD28^(+)、CD56^(+)在多发性骨髓瘤患者中的表达及其对预后的评估价值  

Expression of CD28^(+)and CD56^(+)in Patients with Multiple Myeloma and Its Evaluation Value on Prognosis

作　　者：潘亚晶[1] 董玉倩 陈素洁 PAN Yajing;DONG Yuqian;CHEN Sujie(The First Affiliated Hospital of Xinxiang Medical University,Xinxiang,453100)

机构地区：[1]新乡医学院第一附属医院,453100

出　　处：《实用癌症杂志》2024年第9期1457-1460,共4页The Practical Journal of Cancer

摘　　要：目的分析CD28^(+)、CD56^(+)在多发性骨髓瘤(MM)患者中的表达及其对预后的评估价值。方法纳入103例MM患者,于入院时检测其CD28、CD56表达情况。随访2年统计预后结果,比较不同预后(存活、病死)患者资料,通过COX分析MM患者预后相关因素,分析CD28^(+)、CD56^(+)与MM患者国际分期系统(R-ISS)分期、β2微球蛋白(β2-MG)的相关性,绘制DCA曲线分析CD28^(+)、CD56^(+)预测MM患者预后的价值。结果103例MM患者2年内共19例病死,84例存活,2年存活率为81.55%(84/103)。COX分析显示,R-ISS分期Ⅲ期、β2-MG、CD28^(+)、CD56^(+)均为MM患者病死的影响因素(HR>1,P<0.05)。Kendall's tau-b相关性分析显示,CD28^(+)、CD56^(+)均与MM患者R-ISS分期呈正相关(P<0.05);Spearson相关性分析显示,CD28^(+)表达与MM患者β2-MG水平呈正相关(P<0.05),CD56^(+)表达与MM患者β2-MG水平无相关(P>0.05)。DCA曲线分析显示,当高风险阈值为0.0~0.31时,CD28^(+)、CD56^(+)表达预测MM患者预后净受益率大于0,有临床意义,净受益率最大值为0.184。结论CD28^(+)、CD56^(+)在MM患者中表达异常,对预后有一定预测价值。Objective To analyze the expression of CD28^(+)and CD56^(+)in patients with multiple myeloma(MM)and its evaluation value on prognosis.Methods 103 patients with MM were included.The expression of CD28 and CD56 was detected on admission.The prognosis results were followed up for 2 years.The data of patients with different prognosis(survival and death)were compared.COX was used to analyze the prognostic factors of MM patients.The correlation between CD28 and CD56 expression and international staging system(R-ISS)stage andβ2-microglobulin(β2-MG)of MM patients was analyzed.DCA curve was drawn to analyze the value of CD28^(+)and CD56^(+)expression in predicting the prognosis of MM patients.Results Among 103 MM patients,a total of 19 cases of MM patients died within 2 years,and 84 cases survived.The 2-year survival rate was 81.55%(84/103).Cox analysis showed that R-ISS stageⅢ,β2-MG,CD28 and CD56 were the influencing factors of death in MM patients(HR>1,P<0.05).Kendall's tau-b correlation analysis showed that CD28^(+)and CD56^(+)were positively correlated with R-ISS stage in MM patients(P<0.05).Spearson correlation analysis showed that,the expression of CD28^(+)was positively correlated with the level ofβ2-MG in MM patients(P<0.05),the expression of CD56^(+)was not correlated with the level ofβ2-MG in MM patients(P>0.05).DCA curve analysis showed that when the high-risk threshold was 0.0-0.31,the net benefit rate of CD28^(+)and CD56^(+)expression in predicting the prognosis of MM patients was greater than 0,which was of clinical significance,and the maximum net benefit rate was 0.184.Conclusion The abnormal expression of CD28^(+)and CD56^(+)in MM patients has certain predictive value for prognosis.

关 键 词：多发性骨髓瘤 CD28^(+) CD56^(+) 

分 类 号：R733.3[医药卫生—肿瘤]