老年营养风险指数与进展期非小细胞肺癌患者预后的相关性分析  

Analysis on association between geriatric nutritional risk index and prognosis of advanced non-small cell lung cancer patients

作　　者：高珊[1] 吕艳茹[2] 谢嫣嫣[1] 黄琴 陈晓丹[1] 陆水[1] 竺建芳 蒿艳蓉[1] GAO Shan;LYU Yanru;XIE Yanyan;HUANG Qin;CHEN Xiaodan;LU Shui;ZHU Jianfang;HAO Yanrong(Ward 1 of the Department of Medical Oncology in Clinical Oncology Center,Guangxi Academy of Medical Sciences·The People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,Guangxi,China;Department of Scientific Research Cooperation,Guangxi Academy of Medical Sciences·The People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,Guangxi,China;Department of Oncology and Chemotherapy,Red Cross Hospital of Yulin City,Yulin 537000,Guangxi,China)

机构地区：[1]广西医学科学院·广西壮族自治区人民医院临床肿瘤中心肿瘤内科一区,广西南宁530021 [2]广西医学科学院·广西壮族自治区人民医院科研合作部,广西南宁530021 [3]广西玉林市红十字会医院肿瘤化疗科,广西玉林537000

出　　处：《右江医学》2024年第7期591-598,共8页Chinese Youjiang Medical Journal

基　　金：广西重点研发计划项目(桂科-AB21196012);广西卫健委自筹经费科研课题(Z20210544)。

摘　　要：目的探讨老年营养风险指数(GNRI)与进展期非小细胞肺癌(NSCLC)患者预后的相关性。方法回顾性分析2017年1月至2021年12月在广西壮族自治区人民医院肿瘤内科确诊并接受一线标准化疗的驱动基因阴性的老年进展期NSCLC患者共117例。收集患者的基线资料、实验室检验及影像学结果,并通过多种方式随访患者的生存状态。结果与高GNRI组(GNRI>98,n=35)相比,低GNRI组(GNRI≤98,n=82)患者更容易出现胸膜转移及白蛋白下降,两组间差异有统计学意义(P<0.05)。根据Kaplan-Meier曲线,低GNRI组具有更差的无进展生存期(9个月vs 19个月,P<0.001)和总生存期(16个月vs 41个月,P<0.001)。单因素及多因素分析显示,低GNRI是影响患者总生存期的独立危险因素(P<0.05)。结论GNRI是老年进展期NSCLC患者疗效及生存简单有效的潜在预测指标,低GNRI可能与预后更差相关。Objective To investigate the relevance of geriatric nutritional risk index(GNRI)on the prognosis of patients with advanced non-small cell lung cancer(NSCLC).Methods A total of 117 elderly advanced NSCLC patients with negative driver gene who were diagnosed in the Department of Medical Oncology of the People's Hospital of Guangxi Zhuang Autonomous Region from January 2017 to December 2021 were retrospectively analyzed.The baseline data of the patients,laboratory test results,and imaging findings were collected,and the survival status of the patients were followed up through various methods.Results Compared with the high GNRI group(GNRI>98,n=35),patients in the low GNRI group(GNRI≤98,n=82)were more likely to experience pleural metastasis and decreased albumin,and difference between the two groups was statistically significant(P<0.05).According to the Kaplan Meier curve,the low GNRI group had worse progression free survival(9 months vs 19 months,P<0.001)and overall survival(16 months vs 41 months,P<0.001).Univariate and multivariate analyses showed that low GNRI was an independent risk factor for overall survival(P<0.05).Conclusion GNRI is a simple and effective potential predictor of outcome and survival in elderly patients with progressive NSCLC,and low GNRI may be associated with worse prognosis.

关 键 词：进展期肺癌 老年营养风险指数 预后 生存分析 

分 类 号：R734.2[医药卫生—肿瘤]