Genetic Variations and Nonalcoholic Fatty Liver Disease:Field Synopsis,Systematic Meta-Analysis,and Epidemiological Evidence  

作　　者：Yamei Li Xiang Xiao Jie Wang Yixu Liu Xiongfeng Pan Haibin Yu Jiayou Luo Miyang Luo 

机构地区：[1]Department of Epidemiology and Health Statistics,School of Public Health,University of South China,Hengyang 421001,Hunan,China [2]Department of Maternal and Child Health,Xiangya School of Public Health,Central South University,Changsha 410008,Hunan,China [3]Supervision and Inspection Department of Shanghai Healthcare Security Bureau,Shanghai 200003,China [4]Department of Epidemiology and Health Statistics,Xiangya School of Public Health,Central South University,Changsha 410008,Hunan,China

出　　处：《Biomedical and Environmental Sciences》2024年第7期762-773,共12页生物医学与环境科学（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China[No.81872641];Natural Science Foundation of Hunan Province[No.2023JJ40357].

摘　　要：Objective To systematically summarize the published literature on the genetic variants associated with nonalcoholic fatty liver disease(NAFLD).Methods Literature from Web of Science,PubMed,and Embase between January 1980 and September 2022 was systematically searched.Meta-analyses of the genetic variants were conducted using at least five data sources.The epidemiologic credibility of the significant associations was graded using the Venice criteria.Results Based on literature screening,399 eligible studies were included,comprising 381 candidate gene association,16 genome-wide association,and 2 whole-exome sequencing studies.We identified 465 genetic variants in 173 genes in candidate gene association studies,and 25 genetic variants in 17 genes were included in the meta-analysis.The meta-analysis identified 11 variants in 10 genes that were significantly associated with NAFLD,with cumulative epidemiological evidence of an association graded as strong for two variants in two genes(HFE,TNF),moderate for four variants in three genes(TM6SF2,GCKR,and ADIPOQ),and weak for five variants in five genes(MBOAT7,PEMT,PNPLA3,LEPR,and MTHFR).Conclusion This study identified six variants in five genes that had moderate to strong evidence of an association with NAFLD,which may help understand the genetic architecture of NAFLD risk.

关 键 词：Nonalcoholic fatty liver disease Genetic association study Genetic variant Systematic review META-ANALYSIS 

分 类 号：R575.5[医药卫生—消化系统]