内镜下可旋转重复开闭软组织夹止血联合奥曲肽、奥美拉唑治疗非静脉曲张性上消化道出血的效果及对凝血功能的影响  

Effect of endoscopic rotary repeated open and close soft tissue clip hemostasis combined with octreotide and omeprazole in the treatment of non-variceal upper gastrointestinal bleeding and its influence on coagulation function

作　　者：苗涛 周黎强 张瑞峰[2] MIAO Tao;ZHOU Liqiang;ZHANG Ruifeng(Chenggu County Hospital,Hanzhong 723200;Hanzhong Central Hospital,Hanzhong 723000,China)

机构地区：[1]城固县医院,陕西汉中723200 [2]汉中市中心医院,陕西汉中723000

出　　处：《临床医学研究与实践》2024年第23期66-69,共4页Clinical Research and Practice

摘　　要：目的探讨内镜下可旋转重复开闭软组织夹止血联合奥曲肽、奥美拉唑治疗非静脉曲张性上消化道出血的效果。方法选取2021年1月至2022年12月收治的120例非静脉曲张性上消化道出血患者,以随机数字表法将其分为对照组与观察组,各60例。对照组采用奥曲肽、奥美拉唑治疗,观察组在对照组基础上行内镜下可旋转重复开闭软组织夹止血治疗。比较两组的治疗效果。结果观察组的即时止血率、止血有效率高于对照组,72 h再出血率低于对照组(P<0.05)。治疗后,观察组的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)短于对照组,D-二聚体(D-D)水平低于对照组,纤维蛋白原(FIB)水平高于对照组(P<0.05)。治疗后,观察组的α-颗粒膜糖蛋白(CD62P)低于对照组,血小板计数(PLT)和血小板聚集率(PAR)高于对照组(P<0.05)。结论内镜下可旋转重复开闭软组织夹止血联合奥曲肽、奥美拉唑治疗非静脉曲张性上消化道出血患者可改善血小板活化功能及凝血功能,提高整体治疗效果。Objective To investigate the effect of endoscopic rotary repeated open and close soft tissue clip hemostasis combined with octreotide and omeprazole in the treatment of non-variceal upper gastrointestinal bleeding.Methods A total of 120 patients with non-variceal upper gastrointestinal bleeding admitted from January 2021 to December 2022 were selected and divided into control group and observation group by random number table method,with 60 cases in each group.The control group was treated with octreotide and omeprazole,and the observation group was treated with endoscopic rotary repeated open and close soft tissue clip hemostasis on the basis of the control group.The therapeutic effects of the two groups were compared.Results The immediate hemostasis rate and hemostasis efficiency of the observation group were higher than those of the control group,and the rebleeding rate at 72 h was lower than that of the control group(P<0.05).After treatment,the prothrombin time(PT)and activated partial thromboplastin time(APTT)in the observation group were shorter than those in the control group,D-dimer(D-D)level was lower than that in the control group,and the level of fibrinogen(FIB)was higher than that in the control group(P<0.05).After treatment,the alpha-granular membrane protein(CD62P)in the observation group was lower than that in the control group,and the blood platelet(PLT)and platelet aggregation ratio(PAR)were higher than those in the control group(P<0.05).Conclusion Endoscopic rotary repeated open and close soft tissue clip hemostasis combined with octreotide and omeprazole in the treatment of patients with non-variceal upper gastrointestinal bleeding can improve platelet activation function and coagulation function,and enhance the overall treatment effect.

关 键 词：可旋转重复开闭软组织夹 奥曲肽 奥美拉唑 非静脉曲张性上消化道出血 

分 类 号：R573.2[医药卫生—消化系统]