合并抗SSA抗体阳性的多发性硬化患者临床特点  

The clinical characteristics of multiple sclerosis patients with positive anti-SSA antibody

作　　者：曹晓宇 郭娟 杨雅然 于织波 周炜 Cao Xiaoyu;Guo Juan;Yang Yaran;Yu Zhibo;Zhou Wei(Department of Rheumatology and Immunology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)

机构地区：[1]首都医科大学附属北京天坛医院风湿免疫科,北京100070

出　　处：《中华风湿病学杂志》2024年第7期472-477,共6页Chinese Journal of Rheumatology

摘　　要：目的探讨合并抗SSA抗体阳性的多发性硬化(MS)患者临床特点。方法回顾性分析2011年12月至2020年5月北京天坛医院住院的抗SSA抗体阳性患者,符合MS诊断的患者纳入到本研究。按照性别、年龄1∶2比例匹配同时期住院的抗SSA抗体阴性的MS患者,比较2组患者的临床特点差异。本研究使用SPSS 24.0软件进行数据分析,用Shapiro-Wilk检验判断计量资料是否符合正态分布;非正态分布的计量资料组间比较使用Mann-WhitneyU检验;分类资料的组间比较采用Fisher确切概率法。结果抗SSA抗体阳性住院患者785例,其中7例为MS患者,MS在抗SSA抗体阳性患者中的比例是0.89%。按照性别、年龄1∶2比例匹配同时期住院的抗SSA抗体阴性的MS患者14例。抗SSA抗体阳性的MS患者,与抗SSA抗体阴性的MS患者在ANA阳性、抗Ro-52抗体阳性的患者比例上,差异有统计学意义(6/7与0/14,P<0.001;4/7与0/14,P=0.006)。2组患者在其他临床特征方面差异无统计学意义(P>0.05)。结论抗SSA阳性的MS患者中出现ANA阳性、抗Ro-52抗体阳性的比例较高。合并抗SSA抗体不影响MS患者临床特征,MS与抗SSA抗体阳性两者之间可能为共存关系。Objective To investigate the clinical characteristics of multiple sclerosis(MS)patients with positive anti-SSA antibody.Methods The data of patients with positive anti-SSA antibody hospitalized in Beijing Tiantan Hospital between December 2011 and May 2020 were retrieved.Patients who fulfilled the diagnosis of MS were enrolled.MS patients with negative anti-SSA antibody hospitalized in the same period were matched based on gender and age in a ratio of 1∶2.The clinical characteristics of MS patients with positive anti-SSA antibody and those with negative anti-SSA antibody were compared.We used SPSS 24.0 statistical software to perform data analysis.The Shapiro-Wilk test was used to determine whether continuous variables conform to a normal distribution.The group differences of non-normal distribution of measurement data were analyzed by Mann-Whitney U test.Fisher exact probability method was used to compare the group differences of categorical variables.P<0.05 was considered statistically significant.Results There were 785 hospitalized patients with anti-SSA positivity.Among these,a total of 7 patients(0.89%)were diagnosed as MS.Fourteen MS patients with negative anti-SSA antibody were included with matched sex and age.There was a statistical significant difference in the frequency of positive antinuclear antibody(ANA)and anti-Ro-52 antibody between MS patients with positive anti-SSA antibody and those with negative anti-SSA(6/7 vs.0/14,P<0.001;4/7 vs.0/14,P=0.006,respectively).No statistical significant difference in other clinical features was detected between the two groups(P>0.05).Conclusion The frequency of ANA and anti-Ro-52 antibody positivity is significantly higher in MS patients with positive anti-SSA antibody.Our results suggest the presence of positive anti-SSA antibody has no affect on clinical features of MS.The relationship between MS and anti-SSA positivity may be incidently coexisted.

关 键 词：多发性硬化 干燥综合征 抗SSA抗体 

分 类 号：R744.51[医药卫生—神经病学与精神病学]