富马酸亚铁联合营养支持对营养不良儿童营养、免疫及血液指标的影响  

Effects of Ferrous Fumarate Combined with Nutritional Support on Nutritional,Immune and Blood Indexes of Malnourished Children

作　　者：田越[1] 花琛[1] 李蕴志 TIAN Yue;HUA Chen;LI Yunzhi(Child Healthcare Department,Yantaishan Hospital,Yantai 264001,China)

机构地区：[1]烟台市烟台山医院儿童保健科,山东烟台264001

出　　处：《标记免疫分析与临床》2024年第7期1292-1297,共6页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨富马酸亚铁联合营养支持对营养不良儿童营养、免疫及血液指标的影响。方法前瞻性选取2020年1月至2023年6月烟台市烟台山医院收治100例的营养不良的患儿,按照随机数字方法分为对照组及研究组,各50例。研究组在营养支持基础上口服富马酸亚铁,对照组采用单纯营养支持,连续治疗4周。比较两组患儿治疗后临床疗效及不良反应,以及营养指标、血液指标及免疫指标水平。结果研究组患儿临床有效率(86.00%)明显高于对照组(68.00%),差异有统计学意义(χ^(2)=4.574,P=0.033)。治疗后,研究组患儿体质量指数(BMI)、转铁蛋白(TRF)及前清蛋白(PAB)、白蛋白、前白蛋白、血清铁(SI)、血红蛋白(Hb)及网织红细胞(Ret)水平明显高于对照组(P<0.05);IgA、IgG、IgE明显高于对照组(t=4.602,3.393,2.772,P<0.05),IgM水平明显低于对照组(t=3.805,P=0.001);两组患儿不良反应比较差异无统计学意义(P>0.05)。结论富马酸亚铁联合营养支持可显著提高营养不良患儿营养状态及免疫功能,改善铁代谢障碍及提高血红蛋白含量,且不良反应少,安全性较高,值得应用。Objective To investigate effects of ferrous fumarate combined with nutritional support on nutritional,immune and blood indexes of malnourished children.Methods A total of 100 malnourished children admitted to Yantai Mountain Hospital from January,2020 to June,2023 were prospectively selected and divided into a control group and a study group with 50 cases in each group according to random number method.The study group received oral ferrous fumarate on in addition to nutritional support,while the control group received pure nutritional support for 4 weeks.The clinical efficacy,adverse reactions,nutritional indexes,blood indexes and immune indexes were compared between the two groups after treatment.Results The clinical efficacy rate of the study group(86.00%)was significantly higher than that of the control group(68.00%)(χ^(2)=4.574,P=0.033).After treatment,the study group had significantly higher levels of body mass index(BMI),transferrin(TRF),prealbumin(PAB),albumin,pre-albumin,serum iron(SI),hemoglobin(Hb),and reticulocytes,compared to the control group(P<0.05).Levels of IgA,IgG,and IgE were significantly higher in the study group compared to the control group(t=4.602,3.393,2.772,P<0.05),while IgM levels were significantly lower in the study group compared to the control group(t=3.805,P=0.001).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Ferrous fumarate combined with nutritional support can significantly improve the nutritional status and immune function of malnourished children,as well as iron metabolism disorders,also can increase hemoglobin levels,with fewer adverse reactions and a high level of safety.Our study suggests that it is worth applying in clinical practice.

关 键 词：儿童 营养不良 富马酸亚铁 营养支持 免疫球蛋白 营养 不良反应 

分 类 号：R723.13[医药卫生—儿科]