血管源性脑白质高信号消退的神经影像学研究进展  

Neuroimaging advances in the regression of white matter hyperintensity of presumed vascular origin

作　　者：曹瑾怡 仲伟逸 应云清 程忻[1] Cao Jinyi;Zhong Weiyi;Ying Yunqing;Cheng Xin(Department of Neurology,Huashan Hospital,Fudan University,National Center for Neurological Disorders,National Clinical Research Centre for Aging and Medicine,Shanghai 200040,China)

机构地区：[1]复旦大学华山医院神经内科,国家神经疾病医学中心,国家老年疾病临床医学研究中心,上海200040

出　　处：《中华神经科杂志》2024年第8期907-914,共8页Chinese Journal of Neurology

基　　金：上海市卫生健康委员会卫生健康学科带头人计划(2022XD022)。

摘　　要：血管源性脑白质高信号是脑小血管病的影像特征之一,在老年人群中尤为常见。既往认为脑白质高信号负荷通常缓慢增多,并与认知功能减退密切相关,然而其病理机制仍未阐明,且尚无有效治疗方法。近年来一些研究报道了脑白质高信号消退的现象,并发现进展和消退可交替出现,提示其纵向改变并非是单向的。文中对血管源性脑白质高信号消退相关的神经影像学研究进行系统综述,旨在增进对脑白质高信号动态变化的理解,为寻找干预靶点提供线索。As one of the imaging features of cerebral small vessel disease,white matter hyperintensity(WMH)of presumed vascular origin is quite common in the elderly.The burden of WMH is thought to progress slowly over time and is significantly associated with cognitive decline.However,the pathogenesis of WMH remains unclear and there is no effective treatment available.Recent studies have reported that some WMH lesions can regress during follow-up,along with progression and regression occurring alternately,suggesting that longitudinal changes in WMH are not unidirectional.This article presents a systematic review of current neuroimaging studies on WMH regression to enhance the understanding of dynamic changes in WMH and to provide new theoretical evidence for WMH intervention.

关 键 词：脑小血管病 神经影像 认知障碍 血管源性脑白质高信号 消退 

分 类 号：R743[医药卫生—神经病学与精神病学]