前馈环与反馈环的动力学行为研究进展  

Advances in the Dynamic Behavior of Feedforward Loop and Feedback Loop

作　　者：祁宏 马中琳 曹旭清 QI Hong;MA Zhonglin;CAO Xuqing(Complex Systems Research Center,Shanxi University,Taiyuan 030006,China)

机构地区：[1]山西大学复杂系统研究所,山西太原030006

出　　处：《山西大学学报（自然科学版）》2024年第4期717-726,共10页Journal of Shanxi University(Natural Science Edition)

基　　金：国家自然科学基金(12226317)。

摘　　要：模体是网络中频繁出现的局部连接模式,是组成网络的基础构件。前馈环和反馈环是生物网络中最常见的两种模体,研究者们针对它们分别做了大量研究。虽然很多证据表明生物网络中有前馈环和反馈环共存的实例,但目前尚缺乏对这种耦合网络动力学行为的研究。本综述首先介绍了前馈环的结构与功能;然后总结了反馈环的结构与动力学行为,着重阐述了多稳态和振荡这两种动力学行为的研究现状;最后列举了一些既包含前馈环又包含反馈环结构的生物学实例,强调了研究此类耦合网络动力学行为的重要性。Networks are composed of a small set of recurring interaction patterns called motifs.Two of the most common motifs in the biological networks are feedforward loop(FFL) and feedback loop(FBL),which have been extensively studied,respectively.Although there are many instances that FFL and FBL co-exist in biological networks,there is still a lack of clear understanding on their dynamic behaviors.In this review,we first describe the structure and function of the FFL.Then,we summarize the structure and dynamical behavior of FFL,focusing on the current status of research on two important dynamical behaviors,i.e.,multistability and oscillation.Finally,we give some biological examples that contain both FFL and FBL,emphasizing the importance of studying the dynamical behavior of such coupled networks.

关 键 词：模体 前馈环 反馈环 多稳态 振荡 

分 类 号：O29[理学—应用数学]