β-环糊精-磁性纳米共聚物包合吖啶黄的特性研究  

Study on Inclusion Interaction of β-Cyclodextrin/Magnetic Nanocopolymers to Acridine Yellow

作　　者：王中慧[1] 张国帅 王松柏[2] WANG Zhonghui;ZHANG Guoshuai;WANG Songbai(Department of Chemical and Material Engineering,Lyuliang University,Lishi 033001,China;School of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,China)

机构地区：[1]吕梁学院化工与材料工程系,山西离石033001 [2]山西大学化学化工学院,山西太原030006

出　　处：《山西大学学报（自然科学版）》2024年第4期833-841,共9页Journal of Shanxi University(Natural Science Edition)

基　　金：山西省教育厅山西省高等学校科技创新计划项目(2023L370);吕梁市重点研发计划(高新)项目(2021GXYF-2-63);吕梁市高层次科技人才项目(2023RC23)。

摘　　要：本文采用层层组装方法制备了具有磁性纳米内芯和包合吸附活性外层的β-环糊精/Fe_(3)O_(4)磁性纳米共聚物(β-cyclodextrin/Fe_(3)O_(4)Magnetic nanocopolymers,β-CD-MNPs),磁性内芯使得分离更加方便,而包合吸附活性层通过主客体超分子化学作用提高目标物的吸附选择性。首先,采用化学共沉淀法制Fe_(3)O_(4)磁性纳米粒子(Fe_(3)O_(4)Magnetic nanoparticles,MNPs),然后制备得到3-氨基丙基-三乙氧基硅烷(3-Aminopropyl triethoxysilane,APTES)表面修饰的Fe_(3)O_(4)磁性纳米粒子(APTES-MNPs)。接着,采用合成的6-对甲苯磺酰基-β-环糊精(6-TsO-β-CD)与APTES-MNPs进行共价缩合反应,得到β-CD-MNPs,共聚物的平均粒径为(10.91±2.41)nm。紫外-可见分光光度法检测在NH_(3)-NH_(4)Cl缓冲介质(pH 10)中,β-CD-MNPs对致癌性的碱性荧光染料吖啶黄(AY)的包合情况。结果表明:β-CD-MNPs对AY的包合过程基本符合Langmuir单分子层吸附机理,最大包合量28.9 mg·g^(-1),包合剂β-CD-MNPs回收率可达93%。This article adopts a layer by layer assembly method to synthesize β-cyclodextrin/Fe_(3)O_(4) nanocomposite(β-CD-MNPs)with magnetic core and inclusion adsorption active outer layer.The magnetic nanocore makes separation more convenient,while the active layer enhances the adsorption selectivity of the target analyte through host-guest supramolecular chemical interactions.First,Fe_(3)O_(4) magnetic nanoparticles(MNPs) were prepared by chemical coprecipitation method;Second,Fe_(3)O_(4) magnetic nanoparticles(APTES MNPs) with surface modification of 3-aminopropyl triethoxysilane(APTES) were obtained;Next,the synthesized 6-p-toluenesulfonyl-β-cyclodextrin(6-TsO-β-CD) undergoes covalent condensation reaction with APTES-MNPs to obtain β-CD-MNPs.The average particle size of β-CD-MNPs copolymers is(10.91 ± 2.41) nm.UV-Visible spectrophotometry was used to detect β-CD inclusion of carcinogenic alkaline fluorescent dye acridine yellow(AY) by β-CD-MNPs in NH_(3)-NH_(4)Cl buffer medium(pH 10).The results indicate that the inclusion process of β-CD-MNPs for AY basically follows the Langmuir monolayer adsorption mechanism,with a maximum inclusion amount of 28.9 mg·g^(-1) and the recovery rate of the inclusion agent β-CD-MNPs can reach 93%.

关 键 词：磁性纳米粒子 Β-环糊精 共聚物 吖啶黄 包合量 

分 类 号：O436[机械工程—光学工程]