帕金森病自主神经功能障碍丘脑底核脑深部电刺激术治疗进展  

Research progress of subthalamic nucleus deep brain stimulation in treatment of autonomic nerve dysfunction in Parkinson's disease

作　　者：张峰[1] 孟凡刚[2] ZHANG Feng;MENG Fan-gang(Department of Neurosurgery,The First Hospital of Hebei Medical University,Xuanwu Hospital of Capital Medical University Hebei Hospital,Shijiazhuang 050031,Hebei,China;Beijing Neurosurgical Institute,Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)

机构地区：[1]河北医科大学第一医院、首都医科大学宣武医院河北医院神经外科,石家庄050031 [2]北京市神经外科研究所、首都医科大学附属北京天坛医院神经外科,100070

出　　处：《中国现代神经疾病杂志》2024年第7期510-515,共6页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：河北省省级科技计划资助项目(项目编号:21377736D)。

摘　　要：自主神经功能障碍是帕金森病的常见非运动症状,发生率高,涉及多系统功能紊乱,临床表现多样,严重影响患者生活质量。自主神经功能障碍可能是帕金森病晚期的主要症状,也是患者病残的主要原因。丘脑底核脑深部电刺激术(STN-DBS)是帕金森病中晚期的有效治疗方法,对运动症状的改善作用已得到广泛认可,但对自主神经功能障碍的作用尚未完全阐明。本文综述STN-DBS对帕金森病自主神经功能障碍的治疗进展,提高临床对自主神经功能障碍症状的重视程度,并对术前评估、靶点选择、刺激参数设定、药物调整、术后疗效判定等得以综合考虑,制定个体化治疗方案。Autonomic nerve dysfunction is a common non-motor symptom of Parkinson's disease(PD).It has a high incidence and involves multiple organ system disorders with various manifestations,seriously affecting the quality of life.Autonomic nerve dysfunction can be a major symptom of advanced PD and a major cause of disability.Subthalamic nucleus deep brain stimulation(STN-DBS)is an effective treatment for advanced PD,and its improvement of motor symptoms in PD patients has been widely recognized.However,the effect of STN-DBS on the symptoms of autonomic nerve dysfunction in PD patients is still unclear.Here,the efficacy of STN-DBS on PD autonomic nerve dysfunction is briefly reviewed.Therefore,we should pay more attention to the symptoms of autonomic nerve dysfunction in PD patients,and conduct preoperative evaluation of DBS in PD patients,so as to comprehensively consider the postoperative efficacy,target selection,stimulus parameter setting,drug adjustment,develop an individualized treatment plan.

关 键 词：帕金森病 自主神经系统 深部脑刺激法 丘脑底核 综述 

分 类 号：R742.5[医药卫生—神经病学与精神病学]