聚多巴胺微胶囊的构建及其应用  

Preparation and Applications of Polydopamine Microcapsules

作　　者：李红 陈蓉 焦龙[1] 李洁龄 Hong Li;Rong Chen;Long Jiao;Jieling Li(College of Chemistry and Chemical Engineering,Xi’an Shiyou University,Xi’an 710065,China;State Key Laboratory of Biochemical Engineering,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China)

机构地区：[1]西安石油大学化学化工学院,西安710065 [2]中国科学院过程工程研究所生化工程国家重点实验室,北京100190

出　　处：《化学进展》2024年第6期878-892,共15页Progress in Chemistry

基　　金：陕西省创新人才推进计划-青年科技新星项目(No.2021KJXX-39);陕西省高层次人才项目资助。

摘　　要：聚合物微胶囊具有密度低、比表面积大、渗透性好和负载量高等诸多特性,并且其组成、尺寸和表面性质具有丰富的可调性,因而广泛应用于生物医学、催化、光学及环境保护等领域。其中,聚多巴胺微胶囊具有优异的生物相容性、荧光淬灭性、强黏附性、高反应性和独特的光热转换能力,而且可以通过一步法组装策略方便地制备获得,因而受到研究人员的广泛关注。本文综述了聚多巴胺微胶囊的构建及其应用的最新研究进展。首先介绍了聚多巴胺微胶囊的常见制备方法,包括硬模板法、软模板法以及功能化微胶囊的构建策略。之后详细综述了聚多巴胺微胶囊在药物递送、癌症治疗、催化、抗菌及农药控释领域的应用。最后,本文提出了推进聚多巴胺微胶囊领域发展的研究方向。Polymer microcapsules possess a multitude of characteristics,including low density,large specific surface area,good permeability,and high loading capacity.Furthermore,their composition,size,and surface properties can be finely tuned,making them widely applicable in various fields such as biomedicine,catalysis,optics,and environmental protection.Polydopamine microcapsules exhibit good biocompatibility,fluorescence quenching properties,strong adhesion capacity,high reactivity,and unique photothermal conversion capability.They can be conveniently synthesized using a one-step assembly strategy,thus attracting significant attention from researchers.The review provides an overview of the latest research progress in the construction and applications of polydopamine microcapsules.Firstly,it introduces the common preparation methods of polydopamine microcapsules,including hard templating,soft templating,and the construction strategy of functionalized microcapsules.Subsequently,it comprehensively summarizes the applications of polydopamine microcapsules in drug delivery,cancer treatment,catalysis,antibacterial agents,and controlled release of pesticides.Finally,this article proposes research directions to advance the development of the field of polydopamine microcapsules.

关 键 词：聚多巴胺 微胶囊 模板法 癌症治疗 催化 

分 类 号：O647.4[理学—物理化学] O648[理学—化学]