两孔腹腔镜结直肠癌根治术对比四孔腹腔镜手术治疗结直肠癌的疗效及对炎症因子和胃肠激素的影响  

Comparing Effect of Two Port Laparoscopic Radical Colorectal Cancer Surgery and Four Port Laparoscopic Surgery in the Treatment of Colorectal Cancer and the Effects on Inflammatory Factors and Gastrointestinal Hormones

作　　者：占正龙 戴海东 ZHAN Zhenglong;DAI Haidong(Macheng Traditional Chinese Medicine Hospital,Macheng 438399,China;不详)

机构地区：[1]麻城市中医医院,湖北麻城438399

出　　处：《中外医学研究》2024年第21期25-28,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究两孔腹腔镜结直肠癌根治术对比四孔腹腔镜手术治疗结直肠癌的疗效及对炎症因子和胃肠激素的影响。方法:选取2021年1月—2023年12月麻城市中医医院收治的80例结直肠癌患者为研究对象,按手术方法的不同分为两孔组(n=40)和四孔组(n=40),分别予以相应治疗。比较两组手术相关指标、术后并发症、炎症因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)]及胃肠激素[胃动素(MTL)、胃泌素(GAS)]水平。结果:两组术中出血量、手术时间比较,差异无统计学意义(P>0.05)。两孔组首次排气时间、下床活动时间及术后住院时间均短于四孔组,差异有统计学意义(P<0.05)。两孔组术后并发症总发生率(10.00%)低于四孔组(22.50%),差异无统计学意义(P>0.05)。术后3 d,两组血清CRP、IL-6水平均较术前升高,两孔组较四孔组更低,差异有统计学意义(P<0.05);两组血清MTL、GAS水平均较术前降低,两孔组较四孔组更高,差异有统计学意义(P<0.05)。结论:两孔腹腔镜结直肠癌根治术较四孔腹腔镜手术治疗结直肠癌更有利于患者术后恢复,安全性好,且对炎症反应和胃肠激素的影响更小。Objective:To investigate the therapeutic effect of two port laparoscopic radical resection for colorectal cancer compared to four port laparoscopic surgery,as well as the impact on inflammatory factors and gastrointestinal hormones.Method:80 patients with colorectal cancer admitted to the hospital from January 2021 to December 2023 were selected as the study subjects.And they were divided into two holes group(n=40)and four holes group(n=40)according to different surgical methods,and received corresponding treatment.The levels of surgical related indicators,postoperative complications,inflammatory factors such as C-reactive protein(CRP),interleukin-6(IL-6),and gastrointestinal hormones such as motilin(MTL)and gastrin(GAS)were compared between two groups.Result:There was no statistically significant difference in intraoperative bleeding volume and surgical time between the two groups(P>0.05).The first exhaust time,time to get out of bed,and postoperative hospital stay in the two holes group were shorter than those in the four holes group(P<0.05).The total incidence of postoperative complications in the two holes group(10.00%)was lower than that in the four holes group(22.50%),but the difference was not statistically significant(P>0.05).Three days after surgery,the serum CRP and IL-6 levels in both groups increased on average compared to preoperative levels,but the two holes group was lower than the four holes group(P<0.05).The serum MTL and GAS levels in both groups decreased compared to preoperative levels,but the two holes group was higher than the four holesl group(P<0.05).Conclusion:Two port laparoscopic radical resection for colorectal cancer is more beneficial for postoperative recovery,it has better safety and less impact on inflammatory response and gastrointestinal hormones compared to four holes laparoscopic surgery.

关 键 词：结直肠癌 腹腔镜手术 两孔法 四孔法 炎症因子 胃肠激素 

分 类 号：R735.34[医药卫生—肿瘤]