去雄激素治疗联合钙剂对前列腺癌患者FRAX骨折风险评分的影响  

Effect of Androgen Deprivation Therapy Combined with Calcium on FRAX Fracture Risk Score in Patients with Prostate Cancer

作　　者：欧田昆 OU Tiankun(Shaoguan First People's Hospital,Shaoguan 512000,China)

机构地区：[1]韶关市第一人民医院,广东韶关512000

出　　处：《中外医学研究》2024年第22期138-141,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：韶关市卫生健康科研项目(Y22190)。

摘　　要：目的:探讨去雄激素治疗(ADT)联合钙剂对前列腺癌患者FRAX骨折风险评分的影响。方法:回顾性分析2022年1月—2023年5月韶关市第一人民医院接诊的60例前列腺癌患者的临床资料,按接受ADT过程中是否补充钙剂分为对照组与试验组,各30例。对照组仅进行ADT,试验组在ADT的同时,每日摄取钙剂、维生素D及每周口服阿仑磷酸钠,两组均连续治疗6个月。比较两组治疗前、治疗6个月后髋部骨折风险(HF)、主要骨质疏松骨折风险(MO)、左股骨和腰1~4骨密度、Ⅰ型胶原吡啶交联终肽(ICTP)、血清骨钙素(BGP)、骨特异性碱性磷酸酶(BALP)水平。结果:治疗前,两组骨折风险、骨密度、骨代谢指标比较,差异无统计学意义(P>0.05);治疗6个月后,两组HF、MO均高于治疗前,但试验组低于对照组,两组左股骨、腰1~4骨密度及ICTP、BGP、BALP水平低于治疗前,但试验组高于对照组,差异有统计学意义(P<0.05)。结论:前列腺癌患者接受ADT持续6个月可导致骨折风险升高,骨密度和骨代谢指标降低,在ADT过程中补充钙剂能有效改善FRAX骨折风险评分。Objective:To investigate the effect of androgen deprivation therapy(ADT)combined with Calcium on FRAX fracture risk score in patients with prostate cancer.Method:The clinical data of 60 patients with prostate cancer who admitted to Shaoguan First People's Hospital from January 2022 to May 2023 were retrospectively analyzed,according to whether Calcium was supplemented during ADT,they were divided into the control group and the experimental group,with 30 cases in each group.The control group was only given ADT,while the experimental group was given ADT combined with daily intake of Calcium,Vitamin D and weekly oral administration of Alendronate Sodium,two groups were treated continuously for 6 months.The hip fracture risk(HF),major osteoporotic fracture risk(MO),bone mineral density of left femur and lumbar 1-4,typeⅠcollagen pyridine cross-linked terminal peptide(ICTP),serum osteocalcin(BGP)and bone-specific alkaline phosphatase(BALP)levels were compared between two groups before and 6 months after treatment.Result:Before treatment,there were no significant differences in the fracture risk,bone mineral density and bone metabolism index between the two groups(P>0.05);after 6 months of treatment,the HF and MO of two groups were higher than those before treatment,but those in the experimental group were lower than those in the control group,the bone mineral density of left femur and lumbar 1-4 and the levels of ICTP,BGP and BALP in two groups were lower than those before treatment,but those in the experimental group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:Prostate cancer patients receiving ADT for 6 months can lead to increased fracture risk,decreased bone mineral density and bone metabolism indicators,Calcium supplementation during ADT can effectively improve the FRAX fracture risk score.

关 键 词：前列腺癌 去雄激素治疗 FRAX骨折风险评分 骨密度 骨代谢 

分 类 号：R737.25[医药卫生—肿瘤] R683[医药卫生—临床医学]