癫痫132例外周血三磷酸腺苷结合盒转运子A7、髓样细胞触发受体2的水平及临床意义  

The levels and clinical significance of adenosine triphosphate-binding cassette transporter A7 and triggering receptor expressed on myeloid cells 2 in 132 patients with epilepsy

作　　者：王男 赵旭东 杜艳姣 WANG Nan;ZHAO Xudong;DU Yanjiao(Department of Neurology,Shangqiu Central Hospital,Shangqiu,He'nan 476000,China)

机构地区：[1]商丘市中心医院神经内科,河南商丘476000

出　　处：《安徽医药》2024年第9期1806-1809,共4页Anhui Medical and Pharmaceutical Journal

基　　金：河南省医学科技攻关计划(联合共建)项目(LHGJ20200849)。

摘　　要：目的探究癫痫病人外周血中三磷酸腺苷结合盒转运子A7(ABCA7)、髓样细胞触发受体2(TREM2)的表达水平及与认知功能的关系。方法选取商丘市中心医院2017年6月至2021年7月收治的132例癫痫病人为研究对象,根据蒙特利尔认知评估量表(MoCA)得分将癫痫病人分为两组,认知功能正常组(MoCA≥26分,60例)和认知功能障碍组(MoCA 0~25分,72例)。采用酶联免疫吸附测定(ELISA)检测血清ABCA7、TREM2水平;Spearman法分析相关性、logistic回归分析影响因素、受试者操作特征曲线(ROC曲线)评估预测价值。结果相较于认知功能正常组,认知功能障碍组血清ABCA7[(1.17±0.26)μg/L比(1.53±0.37)μg/L]水平升高,TREM2[(25.14±3.47)ng/L比(20.58±2.52)ng/L]水平降低(t=6.34、8.73,P<0.05)。认知功能障碍病人血清ABCA7水平与MoCA评分呈负相关(r=−0.55,P<0.001),血清TREM2水平与MoCA评分呈正相关(r=0.56,P<0.001)。TREM2、发作持续时间、病程、ABCA7是癫痫病人发生认知功能障碍的影响因素。血清ABCA7、TREM2水平单独及联合预测癫痫病人认知功能障碍的曲线下面积分别为0.79、0.84、0.93,血清ABCA7、TREM2水平联合预测的曲线下面积明显高于二者单独预测(P<0.05)。结论癫痫病人血清中ABCA7的表达水平显著升高,TREM2表达水平显著降低,均为癫痫病人发生认知功能障碍的影响因素,与癫痫病人的认知功能密切相关。Objective To investigate the expression levels of adenosine triphosphate-binding cassette transporter A7(ABCA7)and triggering receptor expressed on myeloid cells 2(TREM2)in the peripheral blood of epilepsy patients and their relationship with cognitive function.Methods From June 2017 to July 2021,132 epilepsy patients admitted to Shangqiu Central Hospital were included as research subjects.According to the Montreal Cognitive Assessment Scale(MoCA)scores,the epilepsy patients were divided into two groups:the normal cognitive function group(MoCA≥26 points,60 patients)and the cognitive dysfunction group(MoCA 0~25 points,72 patients).Enzyme-linked immunosorbent assay(ELISA)was used to detect serum ABCA7 and TREM2 levels.Spearman's method was used to analyze the correlations,logistic regression was used to analyze the influencing factors,and receiver operating characteristic(ROC)curves were used to assess the predictive value.Results Compared to those in the group with normal cognitive function,the serum ABCA7[(1.17±0.26)μg/L vs.(1.53±0.37)μg/L]level in the cognitive impairment group was greater,while the TREM2[(25.14±3.47)ng/L vs.(20.58±2.52)ng/L]level was lower(t=6.34,8.73,P<0.05).The serum ABCA7 level in patients with cognitive dysfunction was negatively correlated with the MoCA score(r=−0.55,P<0.001),and the serum TREM2 level was positively correlated with the Mo‐CA score(r=0.56,P<0.001).TREM2,seizure duration,disease duration and ABCA7 were found to influence the development of cognitive dysfunction(P<0.05).The areas under the curve for cognitive dysfunction in epileptic patients predicted by serum ABCA7 and TREM2 alone and by both serum ABCA7 and TREM2 were 0.79,0.84 and 0.93,respectively,and the areas under the curve for cognitive dysfunction predicted by the combination of serum ABCA7 and TREM2 were significantly greater than those predicted by either of them alone(P<0.05).Conclusion The expression level of ABCA7 in the serum of epileptic patients was significantly greater,while that of TREM2 was s

关 键 词：癫痫 三磷酸腺苷结合盒转运子A7 髓样细胞触发受体2 认知功能障碍 预测 

分 类 号：R742.1[医药卫生—神经病学与精神病学]