腺苷脱氨酶、5′-核苷酸酶及谷胱甘肽还原酶联合检测在评估乙型肝炎患者肝损伤中的临床价值  

Clinical value of combined detection of Adenosine deaminase,5′-nucleotidase,and glutathione reductase in the evaluation of liver injury in patients with hepatitis B

作　　者：黄倩 郭守俊 HUANG Qian;GUO Shoujun(Department of Laboratory,Huichang County People’s Hospital,Ganzhou 342600,Jiangxi,China;Department of Internal Medicine,Ganzhou Cancer Hospital,Ganzhou 341000,Jiangxi,China)

机构地区：[1]赣州市会昌县人民医院检验科,江西赣州342600 [2]赣州市肿瘤医院内科,江西赣州341000

出　　处：《延边大学医学学报》2024年第2期152-154,共3页Journal of Medical Science Yanbian University

摘　　要：[目的]探讨腺苷脱氨酶(ADA)、5′-核苷酸酶(5′-NT)及谷胱甘肽还原酶(GR)联合检测在评估乙型肝炎(CHB)患者肝损伤中的临床价值.[方法]选择2020年1月—2024年6月间就诊的72例CHB患者列入实验组,按照肝损伤不同程度分为轻度组(n=39)、中度组(n=25)、重度组(n=8),另选择同期健康体格检查的72例健康者列入对照组.采集所有研究对象血液样本,检测并比较各组血清ADA、5′-NT、GR水平.[结果]实验组血清ADA、5′-NT、GR水平均明显高于对照组(P<0.05);肝损伤重度组患者的血清ADA、5′-NT、GR水平明显高于中度组、轻度组,中度组血清ADA、5′-NT、GR水平明显高于轻度组,相比较差异均有统计学意义(P<0.05).[结论]血清ADA、5′-NT、GR联合检测可应用于CHB临床辅助诊断及肝损伤程度评估中,为临床诊断与治疗方案制定提供依据.OBJECTIVE To explore the clinical value of combined detection of Adenosine deaminase(ADA),5′-nucleotidase(5′-NT),and glutathione reductase(GR)in the evaluation of liver injury in patients with chronic hepatitis B(CHB).METHODS A total of 72 patients with CHB treated from January 2020 to June 2024 were selected as the experimental group,and divided into mild group(n=39),moderate group(n=25)and severe group(n=8)according to different degrees of liver injury.Additionally,72 healthy individuals who underwent health examinations during the same period were selected as the control group.Blood samples of all subjects were collected,and serum ADA,5′-NT,and GR levels were detected and compared among all groups.RESULTS The serum levels of ADA,5′-NT,and GR in the experimental group were significantly higher than those in the control group(P<0.05).The serum ADA,5′-NT,and GR levels in the severe group were significantly higher than those in the moderate and mild groups,and the serum ADA,5′-NT,and GR levels in the moderate group were significantly higher than those in the mild group,with statistical significance(P<0.05).CONCLUSION The combined detection of serum ADA,5′-NT,and GR can be used in the clinical auxiliary diagnosis of CHB and the evaluation of the degree of liver injury,and provide a basis for formulation of clinical diagnosis and treatment plan.

关 键 词：乙型肝炎 肝损伤 腺苷脱氨酶 5′-核苷酸酶 谷胱甘肽还原酶 

分 类 号：R575[医药卫生—消化系统]