肺疫证治规律探讨与连花清瘟组方新解  

Discussion About Diagnosis and Treatment Regularity of Infectious Lung Disease Epidemic and New Explanation of Lianhua Qingwen Formula

作　　者：贾振华 JIA Zhenhua(National Key Laboratory of Collateral Disease Theory Innovation and Transformation,Hebei Institute of Integrated Chinese and Western Medicine,Shijiazhuang 050035,China)

机构地区：[1]络病理论创新转化全国重点实验室,河北省中西医结合医药研究院,石家庄050035

出　　处：《中国实验方剂学杂志》2024年第17期203-210,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家中医药管理局中医药多学科交叉创新团队项目(ZYYCXTD-D-202206);国家自然科学基金重点项目(82130123)。

摘　　要：病毒类呼吸系统传染病作为严重威胁人类健康的公共卫生事件,属“新病入络”范畴。笔者应用络病理论指导此类疾病防治,提出“肺疫”概念,揭示肺疫“气络-气道-血络”传变规律,提出“卫气同治、表里双解,先证用药、截断病势,整体调节、多靶治疗”积极干预治疗策略。通过系统梳理历代肺疫治疗用药规律,揭示“存正气”和“避毒气”防控总则,分析解毒、通下、芳化等治法应用规律,基于文献整理、数据挖掘、临床经验荟萃分析,传承创新制订中药连花清瘟组方。全方以银翘散、麻杏石甘汤为基础方加减化裁,汲取明代吴又可治疫病用大黄经验,再结合肺疫病变特点,创新加入红景天、广藿香,具有“清热与辛温兼备、解毒与芳化并用、扶正与通腑同施”组方特色,使清而不过凉,温而不助火,扶正不留邪,祛邪不伤正。同时,系列基础和临床研究证实,连花清瘟组方具有应对呼吸系统传染病的独特优势,揭示了肺络病证治理论指导肺疫防控的科学内涵。As a public health event that seriously threatens human health,viral respiratory infectious diseases fall within the scope of"new illness entering collaterals".Collateral disease theory is used to guide prevention and treatment of this type of diseases,thus to propose the concept of infectious lung disease epidemic and reveal its progress rule of"Qi collaterals-Qi pathway-blood collaterals".By analyzing main therapeutic methods including detoxication,precipitation draining and aromatization,this paper proposes active intervention and treatment strategy of"simultaneously treating Wei and Qi,relieving exterior-interior syndrome,using medicine with evidence,stopping the disease tendency,overall adjustment and multi-target therapy".Through systematic summarization of historical medication regularity in infectious lung disease epidemic,this paper demonstrates that"maintaining healthy Qi"and"avoiding harmful Qi"are the general rules of prevention and treatment.Based on literature review,data mining and meta analysis of clinical experiences,this study inherits and innovatively develops the formula of Chinese patent medicine Lianhua Qingwen.The formula is developed through a modification to basic formulae Yinqiaosan and Maxing Shigantang.It learns from Wu Youke's experience in treating epidemic diseases with Rhei Radix et Rhizoma,considers pathological characteristics of infectious lung disease epidemic, and innovatively adds Rhodiolae Crenulatae Radix et Rhizoma andPogostemonis Herba. The new formula is featured by clearing heat, being warm-pungent, function of bothdetoxication and aromatization, as well as simultaneous implementation of strengthening the body resistance andpurging Fu organs. It can clear heat but won't over cool the body, keep the body warm but won't contribute topathogenic fire, strengthening the body resistance but won't retain pathogen, and eliminate pathogen but won'tdamage healthy Qi. Meanwhile, series of basic and clinical studies have demonstrated that Lianhua Qingwenformula has the unique advan

关 键 词：肺络病证治 肺疫 传变规律 新病入络 连花清瘟 方剂 积极干预治疗策略 

分 类 号：R22[医药卫生—中医基础理论] R28[医药卫生—中医学] R24