胃癌患者血清PG、G-17、IL-6、IL-23、IL-17、TNF-α的检测价值  

Detection Value of Serum PG,G-17,IL-6,IL-23,IL-17 and TNF-αin Patients with Gastric Cancer

作　　者：安钰[1] 李扬 王海[1] 苏成东 高瑞萍[1] 于晓兵[1] AN Yu;LI Yang;WANG Hai;SU Cheng-dong;GAO Rui-ping;YU Xiao-bing(Department of Digestive Diseases,People's Hospital of Ningxia Hui Autonomous Region,Yinchuan 750021,Ningxia,China;Department of Endoscopy Center,People's Hospital of Ningxia Hui Autonomous Region,Yinchuan 750021,Ningxia,China)

机构地区：[1]宁夏回族自治区人民医院消化内科,宁夏银川750021 [2]宁夏回族自治区人民医院,内镜中心,宁夏银川750021

出　　处：《医学信息》2024年第16期64-67,共4页Journal of Medical Information

摘　　要：目的分析胃癌患者血清胃蛋白酶原(PG,PGⅠ、PGⅡ)、胃泌素-17(G-17)、白介素(IL)-6、IL-23、IL-17、肿瘤坏死因子-α(TNF-α)的变化及联合检测价值。方法选择2022年1月-2023年2月于我院就诊的胃癌患者122例为观察组,100例体检健康受试者为对照组,进行平行对照研究。PGⅠ、PGⅡ、G-17采用双抗体夹心免疫检测法,IL-6、IL-23、IL-17、TNF-α采用酶联免疫吸附试验(ELISA)检测。比较两组血清PGⅠ、PGⅡ、G-17、IL-6、IL-23、IL-17、TNF-α水平,观察组TNM肿瘤分期Ⅰ~Ⅱ期与Ⅲ~Ⅳ期各血清指标的差异。采用受试者工作特征曲线(ROC曲线)分析各血清指标联合检测对胃癌进展(Ⅲ~Ⅳ期)的预测价值。结果观察组血清PGⅠ低于对照组,血清PGⅡ、G-17、IL-6、IL-23、IL-17、TNF-α水平均高于对照组(P<0.05);胃癌患者TNMⅠ~Ⅱ期血清PGⅠ高于TNMⅢ~Ⅳ期,血清PGⅡ、G-17、IL-6、IL-23、IL-17、TNF-α水平均低于TNMⅢ~Ⅳ期(P<0.05)。单项血清检查中PGⅠ预测胃癌进展AUC较高,为0.976,但各血清指标联合检测预测胃癌进展(Ⅲ~Ⅳ期)的AUC更高,为0.984,特异度98.90%,灵敏度92.60%。结论胃癌患者PGⅡ、G-17、IL-6、IL-23、IL-17、TNF-α水平呈现高表达,PGⅠ水平呈低表达,不同TNM分期差异显著,可预测胃癌进展,以联合检测效用最高。Objective To analyze the changes and combined detection value of serum pepsinogen(PG,PGⅠ,PGⅡ),gastrin-17(G-17),interleukin(IL)-6,IL-23,IL-17 and tumor necrosis factor-α(TNF-α)in patients with gastric cancer.Methods A total of 122 patients with gastric cancer who were treated in our hospital from January 2022 to February 2023 were selected as the observation group,and 100 healthy subjects were selected as the control group for parallel control study.PGI,PGII and G-17 were detected by double antibody sandwich immunoassay,and IL-6,IL-23,IL-17 and TNF-αwere detected by enzyme-linked immunosorbent assay(ELISA).The levels of serum PGⅠ,PGⅡ,G-17,IL-6,IL-23,IL-17 and TNF-αwere compared between the two groups,and the differences of serum indexes between TNM stageⅠ-ⅡandstageⅢ-Ⅳin the observation group were compared.The receiver operating characteristic curve(ROC curve)was used to analyze the predictive value of combined detection of serum indicators for gastric cancer progression(stageⅢ-Ⅳ).Results The serum PGI in the observation group was lower than that in the control group,and the levels of serum PGⅡ,G-17,IL-6,IL-23,IL-17 and TNF-αwere higher than those in the control group(P<0.05).The levels of serum PGI in patients with gastric cancer at TNM stageⅠ-Ⅱwere higher than those at TNM stageⅢ-Ⅳ,and the levels of serum PGⅡ,G-17,IL-6,IL-23,IL-17 and TNF-αwere lower than those at TNM stageⅢ-Ⅳ(P<0.05).In the single serum examination,the AUC of PGI in predicting the progression of gastric cancer was higher,which was 0.976,but the AUC of the combined detection of serum indexes in predicting the progression of gastric cancer(stageⅢ-Ⅳ)was higher,which was 0.984,the specificity was 98.90%,and the sensitivity was 92.60%.Conclusion The levels of PGⅡ,G-17,IL-6,IL-23,IL-17 and TNF-αin patients with gastric cancer are highly expressed,and the level of PGI is low.There are significant differences in different TNM stages,which can predict the progression of gastric cancer,and the combined dete

关 键 词：胃癌 PGⅠ PGⅡ G-17 IL TNF-Α 

分 类 号：R735.2[医药卫生—肿瘤] R446.11[医药卫生—临床医学]