阿替普酶静脉溶栓联合丁苯酞氯化钠注射液治疗急性缺血性脑卒中的效果  

Effect of alteplase intravenous thrombolysis combined with butylphthalein sodium chloride injection in the treatment of acute ischemic stroke

作　　者：李水康[1] 招汉荣 LI Shui-kang;ZHAO Han-rong(First Department of Neurology,Wuchuan People's Hospital,Wuchuan 524500,Guangdong,CHINA)

机构地区：[1]吴川市人民医院神经内科一区,广东吴川524500

出　　处：《海南医学》2024年第16期2305-2308,共4页Hainan Medical Journal

摘　　要：目的探讨阿替普酶(rt-PA)静脉溶栓联合丁苯酞氯化钠注射液治疗急性缺血性脑卒中(AIS)的效果。方法选择2022年1月至2023年1月吴川市人民医院收治的AIS患者100例作为研究对象,按随机数表法分为观察组和对照组各50例。对照组患者予以rt-PA静脉溶栓治疗,观察组患者在对照组基础上联合丁苯酞氯化钠注射液治疗,两组患者均持续治疗14 d。比较两组患者治疗14 d后的临床疗效,以及治疗前和治疗14 d后的美国国立卫生院卒中量表(NIHSS)评分、改良Rankin评分量表(mRS)评分、脑血流量(CBF)、脑血容量(CBV)和平均通过时间(MTT),比较两组患者出院后随访1年的复发率和再入院率。结果治疗后,观察组患者的临床疗效总有效率为92.00%,明显高于对照组的74.00%,差异有统计学意义(P<0.05);治疗14 d后,观察组患者的NIHSS评分为(10.34±2.27)分,明显低于对照组的(8.15±2.63)分,mRS评分为(72.64±11.40)分,明显高于对照组的(61.21±10.25)分,差异均有统计学意义(P<0.05);治疗14 d后,观察组患者的CBF、CBV分别为(21.43±2.18)mL/(10 g·min)、(2.19±0.23)mL/100 g,明显高于对照组的(19.75±1.85)mL/(10 g·min)、(2.01±0.27)mL/100 g,MTT为(6.34±0.68)s,明显短于对照组的(7.49±0.75)s,差异均有统计学意义(P<0.05);出院后随访1年,观察组患者的再入院率为2.04%,明显低于对照组的14.29%,差异有统计学意义(P<0.05)。结论rt-PA静脉溶栓联合丁苯酞氯化钠注射液治疗AIS患者的疗效显著,且有助于减少短期再入院率,值得临床推广应用。Objective To study the effect of alteplase(rt-PA)intravenous thrombolysis combined with butylphthalein sodium chloride injection in the treatment of acute ischemic stroke(AIS).Methods A total of 100 patients with AIS admitted to Wuchuan People's Hospital from January 2022 to January 2023 were selected and divided into an observation group and a control group by random number table method,with 50 cases in each group.Patients in the control group were treated with rt-PA intravenous thrombolytic therapy,and those in the observation group were treated with butylphthalein sodium chloride injection on the basis of the treatment in the control group,all for 14 days.The clinical efficacy after treatment,and the changes of the National Institutes of Health Stroke Scale(NIHSS)score,modified Rankin Scale(mRS)score,cerebral blood flow(CBF),cerebral blood volume(CBV),and mean transit time(MTT)before and after treatment were compared between the two groups.The recurrence rate and readmission rate during the 1-year follow-up after discharge were compared between the two groups.Results After treatment,the total effective rate in the observation group was 92.00%,which was significantly higher than 74.00%in the control group(P<0.05).After treatment,the NIHSS score in observation group was(10.34±2.27)points,which was significantly lower than(8.15±2.63)points in the control group;mRS Score was(72.64±11.40)points,which was significantly higher than(61.21±10.25)points in the control group;the differences were statistically significant(P<0.05).After treatment,the CBF and CBV in the observation group were(21.43±2.18)mL/(10 g·min)and(2.19±0.23)mL/100 g,which were significantly higher than(19.75±1.85)mL/(10 g·min)and(2.01±0.27)mL/100 g in the control group;the MTT was(6.34±0.68)s,which was significantly shorter than(7.49±0.75)s in the control group;the differences were statistically significant(P<0.05).During the 1-year follow-up after discharge,the readmission rate in the observation group was 2.04%,which was significantly lo

关 键 词：急性缺血性脑卒中 静脉溶栓 阿替普酶 丁苯酞氯化钠注射液 神经功能 预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学]