舒眠胶囊与右佐匹克隆治疗抑郁症轻中度失眠障碍的疗效对比  

Comparison of therapeutic effects between Shumian capsules and eszopiclone in the treatment of mild-to-moderate insomnia disorder in depression

作　　者：李迎春 杨梅 LI Ying-chun;YANG Mei(Tengzhou Mental Health Center,Tengzhou 277533,China)

机构地区：[1]山东省滕州市精神卫生中心药房,277533

出　　处：《中国现代药物应用》2024年第15期93-96,共4页Chinese Journal of Modern Drug Application

摘　　要：目的比较舒眠胶囊与右佐匹克隆治疗抑郁症轻中度失眠障碍的临床效果。方法98例抑郁症轻中度睡眠障碍患者作为研究对象,随机分为对照组与实验组,每组49例。对照组患者服用右佐匹克隆治疗,实验组服用舒眠胶囊治疗。比较两组患者治疗效果、匹兹堡睡眠质量指数(PSQI)评分、汉密尔顿抑郁量表(HAMD)评分、不良反应发生率。结果实验组患者总有效率为95.92%,对照组患者为73.47%,实验组患者总有效率高于对照组患者,对比具有统计学意义(P<0.05)。治疗后,两组患者PSQI评分较治疗前均有所下降,且实验组患者PSQI评分(8.47±1.21)分低于对照组的(9.56±1.56)分,对比具有统计学意义(P<0.05)。治疗后,两组患者HAMD评分较治疗前均有所下降,且实验组患者HAMD评分(9.97±2.72)分低于对照组的(12.14±3.02)分,对比具有统计学意义(t=3.737,P=0.000<0.05)。实验组患者不良反应发生率为4.08%,对照组为12.24%,对比不具有统计学意义(P>0.05)。结论使用舒眠胶囊治疗抑郁症轻中度失眠障碍的效果较右佐匹克隆治疗的效果更好。Objective To compare the clinical effect of between Shumian capsules and eszopiclone in the treatment of mild-to-moderate insomnia disorder in depression.Methods 98 depression patients with mild-tomoderate insomnia disorder were selected as the study subjects.They were randomly divided into a control group and an experimental group,each consisting of 49 patients.The control group received eszopiclone for treatment,while the experimental group received Shumian capsules for treatment.Comparison was made on the treatment effect,Pittsburgh Sleep Quality Index(PSQI)score,Hamilton Depression Scale(HAMD)score,and incidence of adverse reactions between the two groups.Results The total effective rate was 95.92%in the experimental group and 73.47%in the control group;the total effective rate of the experimental group was higher than that of the control group,and there was statistical significance in comparison(P<0.05).After treatment,PSQI score of both groups decreased compared with that before treatment;the experimental group had PSQI score of(8.47±1.21)points,which was lower than(9.56±1.56)points of the control group;there was statistical significance in comparison(P<0.05).After treatment,HAMD score of both groups decreased compared with that before treatment,and the experimental group had HAMD score of(9.97±2.72)points,which was lower than(12.14±3.02)points of the control group;there was statistical significance in comparison(t=3.737,P=0.000<0.05).The incidence of adverse reactions was 4.08%in the experimental group and 12.24%in the control group,and there was no statistical significance in comparison(P>0.05).Conclusion The effect of Shumian capsule for the treatment of mild to moderate insomnia in depression is better than that of eszopiclone.

关 键 词：舒眠胶囊 右佐匹克隆 抑郁症 轻中度失眠障碍 临床效果 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R740[医药卫生—临床医学]