PSMA PET/CT在局限性或局部进展性前列腺癌诊疗中的应用  

Application of PSMA PET/CT in the diagnosis and treatment of localized or locally advanced prostate cancer

作　　者：许宁[1,2] 柯志滨 陈佳茵 XU Ning;KE Zhibin;CHEN Jiayin(Department of Urology,The First Affiliated Hospital of Fujian Medical University,Fuzhou 350005;Department of Urology,National Regional Medical Center,Binhai Campus of The First Affiliated Hospital,Fujian Medical University,Fuzhou 350212,China)

机构地区：[1]福建医科大学附属第一医院泌尿外科,福建福州350005 [2]福建医科大学附属第一医院滨海院区国家区域医疗中心泌尿外科,福建福州350212

出　　处：《现代泌尿外科杂志》2024年第8期667-672,共6页Journal of Modern Urology

摘　　要：前列腺特异性膜抗原正电子发射计算机断层扫描(PSMA PET/CT)是新兴的成像技术,近年来逐渐被应用于局限性或局部进展性前列腺癌的诊断及治疗中。PSMA PET/CT检查可有效减少不必要的活检且其引导下的靶向穿刺活检可显著提高临床显著性前列腺癌(csPCa)的检出率。基于PSMA PET的多影像融合穿刺活检技术可能是未来前列腺癌诊断研究的重点,与传统影像学技术相比,PSMA PET/CT在检测淋巴结转移方面具有优越性。PSMA PET/CT不仅可用于预测Gleason评分、手术切缘情况、术后病理等级等病理特征,还可用于评估前列腺癌患者新辅助治疗疗效、指导制定放射治疗方案、预测生化复发以及检出复发病灶。目前仍需进行更多大规模前瞻性研究进一步证实PSMA PET/CT在局限性或局部进展性前列腺癌诊疗中的应用价值。Prostate-specific membrane antigen positron emission tomography/computed tomography(PSMA PET/CT)is an emerging imaging technique applied in the diagnosis and treatment of localized or locally advanced prostate cancer.It can effectively avoid unnecessary biopsies,and PSMA PET/CT-guided targeted biopsy could significantly improve the detection rate of clinically significant prostate cancer(csPCa).The technology of PSMA PET-based multi-image fusion biopsy may be the emphasis in the research of prostate cancer diagnosis in future.Compared with traditional imaging techniques,PSMA PET/CT is advantageous in detecting lymph node metastasis.It can not only be used to predict the adverse pathological features,including Gleason score,positive surgical margin,and postoperative pathological upgrading,but also to evaluate the efficacy of neoadjuvant therapy,guide radiotherapy regimen,predict biochemical recurrence and detect recurrent lesions.Currently,more large-scale prospective studies are still needed to explore the application of PSMA PET/CT for localized or locally advanced prostate cancer.

关 键 词：前列腺癌 前列腺特异性膜抗原 正电子发射计算机断层扫描 临床显著性前列腺癌 

分 类 号：R737[医药卫生—肿瘤]