口腔微生物群介导炎症反应与动脉粥样硬化研究进展  

Advances on inflammation induced by oral microbiota and atherosclerosis

作　　者：赖敏霖 任悦冉 尹恝[1] LAI Minlin;REN Yueran;YIN Jia(Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院,广州510515

出　　处：《中国神经精神疾病杂志》2024年第6期359-363,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：国家自然科学基金项目(编号:82171317);广东省基础与应用基础研究基金项目(编号:2022A1515010477)。

摘　　要：动脉粥样硬化(atherosclerosis,AS)是导致冠心病、心肌梗死和缺血性脑卒中等疾病的主要危险因素。目前研究提示口腔微生物可潜在地影响AS的发生发展。口腔微生物紊乱不仅与高血糖、肥胖和吸烟等AS危险因素相关,而且可引起局部及全身炎症反应而促进AS进展。靶向口腔微生物的检测和干预,将为诊断和治疗AS性心脑血管疾病提供新思路。Atherosclerosis(AS)is a leading cause of coronary heart disease,myocardial infarction and ischemic stroke.It has been demonstrated that oral microbiome may potentially affect the progression of AS.Oral microbial disorders are not only associated with AS risk factors including hyperglycemia,obesity and smoking,but also contribute to the progression of AS by inducing systematic and local inflammatory responses.Detection and intervention targeted on oral microbiome could provide new insights into the diagnosis and treatment of atherosclerotic cardiovascular disease.

关 键 词：口腔微生物 牙周疾病 动脉粥样硬化 血管疾病 缺血性卒中 炎症 

分 类 号：R78[医药卫生—口腔医学] R543[医药卫生—临床医学] R743